Document Detail

Impact of providing vitamin A to the routine pulmonary care of extremely low birth weight infants.
MedLine Citation:
PMID:  21740337     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to determine if the continued use of vitamin A in a nursery utilizing early surfactant and nasal continuous positive airway pressure (CPAP) was warranted.
STUDY DESIGN: A retrospective, cohort study of appropriately sized, preterm neonates weighing ≤1000 g at birth was conducted. Two time periods were compared: Pre-Vitamin A was composed of extremely low birth weight who were routinely cared for with early nasal CPAP (n = 76); and Post-Vitamin A (n = 102) consisted of ELBWs who were cared for similar to Pre-Vitamin A, but with the addition of vitamin A. Outcome variables included the incidence of BPD and other pulmonary and major neonatal morbidities.
RESULTS: Between Pre-Vitamin A and Post-Vitamin A the incidence of moderate to severe BPD decreased by 11%, from 33% to 22% (p = 0.2). No difference was found in the number of ventilator days or in the incidence of any other neonatal morbidity or mortality, including intraventricular hemorrhage, necrotizing enterocolitis, or patent ductus arteriosus requiring surgical ligation.
CONCLUSION: In a neonatal unit utilizing early surfactant followed by nasal CPAP at delivery, supplementing extremely premature neonates with vitamin A demonstrated a trend towards a decrease in the incidence of moderate to severe BPD; however, this change requires a larger sample to verify in the future.
Alvaro Moreira; Melinda Caskey; Rafael Fonseca; Michael Malloy; Cara Geary
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Publication Detail:
Type:  Journal Article     Date:  2011-07-11
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-04-30     Revised Date:  2013-03-29    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Department of Pediatrics, The University of Texas Medical Branch (UTMB), Texas, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / prevention & control
Cohort Studies
Continuous Positive Airway Pressure
Infant, Extremely Low Birth Weight / physiology*
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / prevention & control*,  therapy
Pulmonary Surfactants / administration & dosage
Retrospective Studies
Treatment Outcome
Vitamin A / administration & dosage*
Reg. No./Substance:
0/Pulmonary Surfactants; 11103-57-4/Vitamin A
Comment In:
J Matern Fetal Neonatal Med. 2013 Mar;26(5):544-5   [PMID:  23134150 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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