Document Detail

Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study.
MedLine Citation:
PMID:  21374756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this randomized study was to examine if a prophylactic percutaneous endoscopic gastrostomy (PEG) for enteral nutrition could prevent malnutrition, reduce hospital stay, and improve health-related quality of life (HRQOL).
METHODS: One hundred thirty-four patients with advanced head and neck cancer were randomized to either prophylactic PEG (study group) or clinical praxis (control group). Patients' weight, body mass index (BMI), need for hospitalization, and HRQOL were noted at 7 occasions during 2 years.
RESULTS: No difference in hospital stay was found. After 6 months, HRQOL was significantly better and the weight loss was significantly less in the study group. The number of malnourished patients were consistently about 10% lower in the study group during the first study year. The study group started to use enteral feeding significantly earlier and for a significantly longer time period (p < .0001).
CONCLUSION: Prophylactic PEG was associated with significantly earlier start and longer use of enteral nutrition, fewer malnourished patients over time, and improved HRQOL at 6 months posttreatment start.
Ewa Silander; Jan Nyman; Mogens Bove; Leif Johansson; Sven Larsson; Eva Hammerlid
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-03-03
Journal Detail:
Title:  Head & neck     Volume:  34     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-10-23     Revised Date:  2014-05-28    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
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MeSH Terms
Aged, 80 and over
Endoscopy, Gastrointestinal / adverse effects,  methods*
Enteral Nutrition / methods*
Follow-Up Studies
Gastrostomy / adverse effects,  methods*
Head and Neck Neoplasms / surgery*
Length of Stay
Malnutrition / prevention & control*
Middle Aged
Quality of Life
Treatment Outcome
Comment In:
JPEN J Parenter Enteral Nutr. 2014 May;38(4):521-3   [PMID:  24755875 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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