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Impact of probiotics on the course of indirect hyperbilirubinemia and phototherapy duration in very low birth weight infants.
MedLine Citation:
PMID:  22937831     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate the efficacy of orally administered Saccharomyces boulardii (S.boulardii) on the course of hyperbilirubinemia and duration of treatment in very low birth weight (VLBW) infants. Methods: Infants with a gestational age of ≤32 weeks and birth weight of ≤1500 g were enrolled. The infants in the study group were given S. boulardii with a dose of 250 mg once a day and the infants in the control group were fed without S. boulardii supplementation. The primary outcome measurements were duration of phototherapy and levels of total bilirubin at the end of phototherapy. Results: A total of 179 infants (81 in the study group and 98 in the control group) were enrolled. The duration of phototherapy was shorter in the study group [1.9 ± 0.86 vs 2.6 ± 0.9 days, p=0.000)]. Feeding intolerance was significantly lower in the study group than in the control group (20.9% vs 47.9%; p= 0.00). Conclusion: S. boulardii supplementation at a dose of 250 mg/day is safe for VLBW infants in the short term and effective in reducing the duration of phototherapy in VLBW infants. We suggest that it provides this effect by improving the feeding intolerance and suppressing the reabsorption of bilirubin into the enterohepatic circulation.
Gamze Demirel; Istemi Han Celik; Omer Erdeve; Ugur Dilmen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-3
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Neonatology, Samsun Maternity and Child Health Hospital, Samsun, Turkey.
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