| Impact of preoperative anxiolytic on surgical site infection in patients undergoing abdominal hysterectomy. | |
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MedLine Citation:
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PMID: 18834731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An increased anxiety may be associated with a higher risk of surgical site infection (SSI), but there is little objective data on the effect of preoperative anxiolytic interventions on SSI. To address this issue, we evaluated the effects of preoperative diazepam on postoperative SSI following abdominal hysterectomy. METHODS: This randomized, double-blinded, placebo-controlled study included 130 patients, American Society of Anesthesiologist physical status 1 or 2. Patients were randomly assigned to receive either oral diazepam 10 mg (n = 65) or placebo (n = 65) the night before and 1 hour prior to surgery. The assessment instruments were the Visual Analogue Scale and the State-Trait Anxiety Inventory. SSI was diagnosed according to the criteria of the Centers for Disease Control and Prevention with standard follow-up of 30 days. RESULTS: The relative risk (RR) was 1.79 (95% confidence interval [CI]: 1.31-2.43), and the number of patients that needed to be treated was 5.2 (95% CI: 2.74-50.76) to prevent 1 additional SSI. The RR for SSI in placebo-treated patients with high postoperative anxiety was 1.65 (95% CI: 1.07-2.56). CONCLUSION: Diazepam-treated patients showed lower postoperative anxiety and lower incidence of SSI up to 30 days after surgery compared with placebo in patients undergoing abdominal hysterectomy. |
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Authors:
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Rosa Levandovski; Maria Beatriz Cardoso Ferreira; Maria Paz Loayza Hidalgo; Cássio Alves Konrath; Daniel Lemons da Silva; Wolnei Caumo |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-10-03 |
Journal Detail:
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Title: American journal of infection control Volume: 36 ISSN: 1527-3296 ISO Abbreviation: Am J Infect Control Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-01-28 Revised Date: 2009-08-14 |
Medline Journal Info:
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Nlm Unique ID: 8004854 Medline TA: Am J Infect Control Country: United States |
Other Details:
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Languages: eng Pagination: 718-26 Citation Subset: IM |
Affiliation:
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Postgraduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesia, Patient-Controlled Anti-Anxiety Agents / therapeutic use* Anxiety / prevention & control* Diazepam / therapeutic use* Double-Blind Method Female Humans Hysterectomy / adverse effects* Incidence Logistic Models Middle Aged Pain Measurement Pain, Postoperative / drug therapy*, prevention & control Postoperative Complications / drug therapy, epidemiology Preoperative Care Risk Surgical Wound Infection / epidemiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 439-14-5/Diazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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