Document Detail

Impact of polycystic ovary syndrome on selected indicators of in vitro fertilization and intracytoplasmic sperm injection treatment success.
MedLine Citation:
PMID:  19368509     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To examine the effect of polycystic ovary syndrome (PCOS), a marker of the metabolic syndrome, on selected indicators of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment success. METHODS: A retrospective cohort study was conducted using existing data on 69 IVF/ICSI treatment cycles undergone by PCOS women and a caliper-matched sample of 69 IVF/ICSI treatment cycles undergone by non-PCOS women over a 7-year period at a major fertility treatment center. Matching criteria were age and date at IVF/ICSI treatment initiation. Process and outcome measures were used to define successful IVF/ICSI treatment. Statistical significance was determined at an alpha level of 0.05. RESULTS: The total number of oocytes and the number of immature oocytes retrieved in the process of an IVF/ICSI cycle were significantly higher in the context of PCOS. No significant differences were observed among PCOS and non-PCOS groups on various IVF/ICSI cycle outcomes, including high-grade embryo, pregnancy achievement, miscarriage, and live birth status. CONCLUSIONS: Although IVF/ICSI yields more oocytes in the context of PCOS, IVF/ICSI outcomes do not differ significantly by PCOS status. Prospective cohort studies are needed to examine short-term and long-term health effects of PCOS in the context of IVF/ICSI.
Hind A Beydoun; Laurel Stadtmauer; Yueqin Zhao; Helena Russell; David O Matson; Sergio Oehninger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  18     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-23     Citation Subset:  IM    
Graduate Program in Public Health, Eastern Virginia Medical School, 1123 Lewis Hall, 700 W. Olney Road, Norfolk, VA 23501-1980, USA.
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MeSH Terms
Cohort Studies
Embryo Transfer / statistics & numerical data*
Infertility, Female / epidemiology*,  therapy
Polycystic Ovary Syndrome / epidemiology*,  therapy
Pregnancy Outcome / epidemiology
Retrospective Studies
Sperm Injections, Intracytoplasmic / statistics & numerical data*
Women's Health
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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