Document Detail

Impact of point spread function correction in standardized uptake value quantitation for positron emission tomography images: a study based on phantom experiments and clinical images.
MedLine Citation:
PMID:  24953319     Owner:  NLM     Status:  In-Data-Review    
While point spread function (PSF)-based positron emission tomography (PET) reconstruction effectively improves the spatial resolution and image quality of PET, it may damage its quantitative properties by producing edge artifacts, or Gibbs artifacts, which appear to cause overestimation of regional radioactivity concentration. In this report, we investigated how edge artifacts produce negative effects on the quantitative properties of PET. Experiments with a National Electrical Manufacturers Association (NEMA) phantom, containing radioactive spheres of a variety of sizes and background filled with cold air or water, or radioactive solutions, showed that profiles modified by edge artifacts were reproducible regardless of background μ values, and the effects of edge artifacts increased with increasing sphere-to-background radioactivity concentration ratio (S/B ratio). Profiles were also affected by edge artifacts in complex fashion in response to variable combinations of sphere sizes and S/B ratios; and central single-peak overestimation up to 50% was occasionally noted in relatively small spheres with high S/B ratios. Effects of edge artifacts were obscured in spheres with low S/B ratios. In patient images with a variety of focal lesions, areas of higher radioactivity accumulation were generally more enhanced by edge artifacts, but the effects were variable depending on the size of and accumulation in the lesion. PET images generated using PSF-based reconstruction are therefore not appropriate for the evaluation of SUV.
Akihiro Nakamura; Yasuo Tanizaki; Miho Takeuchi; Shigeru Ito; Yoshitaka Sano; Mayumi Sato; Toshihiko Kanno; Hiroyuki Okada; Tatsuo Torizuka; Sadahiko Nishizawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nihon Hoshasen Gijutsu Gakkai zasshi     Volume:  70     ISSN:  0369-4305     ISO Abbreviation:  Nihon Hoshasen Gijutsu Gakkai Zasshi     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505722     Medline TA:  Nihon Hoshasen Gijutsu Gakkai Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  542-8     Citation Subset:  IM    
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