| Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 17981548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic heart failure (CHF) is a condition characterized by exercise intolerance. The level of activity tolerated by an individual cannot be predicted by classical parameters of left ventricular performance. Therefore, considerable attention has been focused on the role of peripheral factors such as skeletal muscle, which are determinants of work capacity. In recent years, many alterations in the skeletal muscle have been described in patients with chronic heart failure. This knowledge has dramatically changed the treatment of patients with CHF. Previously, patients were asked to avoid excessive strain and physical exercise. Recently, however, patients are asked to participate in a supervised physical training program to increase their exercise capacity and to counteract the molecular changes occurring in the skeletal muscle. This review will focus on molecular and biochemical alterations especially in the skeletal muscle and how these alterations are influenced by exercise training finally contributing to better skeletal muscle performance. |
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Authors:
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Volker Adams; Christian Doring; Gerhard Schuler |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 302-11 Citation Subset: IM |
Affiliation:
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University Leipzig, Heart Center Leipzig, Leipzig, Germany. adav@medizin.unileipzig.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Chronic Disease Cytokines / metabolism Heart Failure / metabolism, pathology* Humans Inflammation Insulin-Like Growth Factor I / metabolism Mitochondria / metabolism Muscle, Skeletal / metabolism, pathology* Oxidative Phosphorylation Oxidative Stress Physical Conditioning, Animal Proteasome Endopeptidase Complex / metabolism Ubiquitin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Ubiquitin; 67763-96-6/Insulin-Like Growth Factor I; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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