Document Detail


Impact of peritoneal transport characteristics on cardiac function in paediatric peritoneal dialysis patients: a Turkish Pediatric Peritoneal Dialysis Study Group (TUPEPD) report.
MedLine Citation:
PMID:  20139065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The peritoneal equilibration test (PET) is recommended in paediatric peritoneal dialysis (PD) patients to assist prescription management. Despite contradictory reports, high transporter status is associated with reduced survival rate in adults. Since cardiac disease is one of the main causes of mortality in paediatric PD patients, we aimed to evaluate whether transport features have any effect on biochemical data and cardiac function in this group. METHODS: One hundred and ten PD patients (13 +/- 5 years, PD vintage: 31 +/- 27 months) were enrolled into the study. Four-hour dialysate/plasma creatinine ratio was used for differentiating PET groups. Thirty-eight patients were high transporters, 29 were high-average transporters and 43 were low-average/low transporters. Echocardiography was performed in all subjects. RESULTS: Age, PD vintage, dialysate glucose concentration, ultrafiltration volume, urine volume and blood pressure levels were similar in all PET groups. No biochemical or echocardiographic data (ejection fraction, fractional shortening, left ventricular mass index, myocardial performance index, power Doppler E/tissue Doppler E ratio reflecting diastolic function) were different among PET groups except lower albumin (P = 0.025) levels in high transporters and higher high-sensitivity C-reactive protein (P = 0.026) levels in high and high-average transporters compared to other transport groups. CONCLUSIONS: Cardiac structural and functional abnormalities are highly prevalent among paediatric PD patients. Transport rates did not have a significant effect on biochemical parameters or cardiac structural/functional parameters. It might be suggested that being a high transporter does not provide a disadvantage in terms of atherogenic tendency and cardiac disease in paediatric PD patients. Oligoanuria, anaemia and hypertension were independent predictors of cardiac disease.
Authors:
Sevcan A Bakkaloglu; Arda Saygili; Lale Sever; Nejat Aksu; Aytul Noyan; Sema Akman; Mesiha Ekim; Beyza Doganay; Nurdan Yildiz; Figen Akalin; Salim Caliskan; Orhan D Kara; Ali Duzova; Alper Soylu; Semra Atalay
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Publication Detail:
Type:  Congresses     Date:  2010-02-04
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  25     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2296-303     Citation Subset:  IM    
Affiliation:
Deparment of Pediatric Nephrology, Gazi University, Ankara, Turkey. sevcan@gazi.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biological Transport / physiology
Cardiovascular Diseases
Case-Control Studies
Child
Echocardiography, Doppler
Female
Heart / physiopathology*
Humans
Kidney Failure, Chronic / mortality,  physiopathology*,  therapy*
Male
Peritoneal Dialysis / methods*
Peritoneum / physiopathology*
Risk Factors
Survival Rate
Turkey

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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