Document Detail


Impact of periodic breathing on V(O2) and V(CO2): a quantitative approach by Fourier analysis.
MedLine Citation:
PMID:  10647868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oscillations in oxygen uptake (V(O2)) and carbon dioxide production (V(CO2)) in patients with chronic heart failure differ in amplitude and phase from the oscillations in ventilation (periodic breathing, PB), leading some to doubt whether they result from PB. We applied Fourier transforms to a pulmonary gas exchange model to quantify the effects of fluctuations in alveolar ventilation (V(A)). We found that PB causes oscillations in V(O2) and V(CO2), but their amplitude and phase are complex, and vary with workload. At low workloads, the relative oscillations in V(O2) and V(CO2) closely mirror the relative oscillations in V(A). But at high workloads, the metabolic oscillations are attenuated (V(O2) most severely), and the V(O2) peaks precede the ventilatory peaks significantly. This study also explains why normal controls simulating PB at higher workloads fail to reproduce the V(O2) and V(CO2) oscillations seen in spontaneous PB of heart failure.
Authors:
D P Francis; L C Davies; K Willson; M Piepoli; S R Seydnejad; P Ponikowski; A J Coats
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  118     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-22     Completed Date:  2000-02-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
Affiliation:
Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK. d.francis@cheerful.com
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MeSH Terms
Descriptor/Qualifier:
Carbon Dioxide / metabolism*
Fourier Analysis*
Humans
Models, Biological
Oxygen Consumption*
Pulmonary Gas Exchange
Respiration*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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