| Impact of periodic breathing on V(O2) and V(CO2): a quantitative approach by Fourier analysis. | |
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MedLine Citation:
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PMID: 10647868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oscillations in oxygen uptake (V(O2)) and carbon dioxide production (V(CO2)) in patients with chronic heart failure differ in amplitude and phase from the oscillations in ventilation (periodic breathing, PB), leading some to doubt whether they result from PB. We applied Fourier transforms to a pulmonary gas exchange model to quantify the effects of fluctuations in alveolar ventilation (V(A)). We found that PB causes oscillations in V(O2) and V(CO2), but their amplitude and phase are complex, and vary with workload. At low workloads, the relative oscillations in V(O2) and V(CO2) closely mirror the relative oscillations in V(A). But at high workloads, the metabolic oscillations are attenuated (V(O2) most severely), and the V(O2) peaks precede the ventilatory peaks significantly. This study also explains why normal controls simulating PB at higher workloads fail to reproduce the V(O2) and V(CO2) oscillations seen in spontaneous PB of heart failure. |
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Authors:
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D P Francis; L C Davies; K Willson; M Piepoli; S R Seydnejad; P Ponikowski; A J Coats |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiration physiology Volume: 118 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-22 Completed Date: 2000-02-22 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: IM |
Affiliation:
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Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK. d.francis@cheerful.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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metabolism* Fourier Analysis* Humans Models, Biological Oxygen Consumption* Pulmonary Gas Exchange Respiration* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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