Document Detail


Impact of pattern of recurrence on clinical outcome of ovarian cancer patients: clinical considerations.
MedLine Citation:
PMID:  16901687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recurrence of disease represents a clinical challenge in ovarian cancer patients. The aim of this study was to analyse the distribution and pattern of recurrence and their association with clinical outcome in a large series of ovarian cancer patients. This study was conducted on 328 primary untreated ovarian cancer patients. For each relapse, information on date of clinical/instrumental recurrence, and pattern of disease presentation were retrieved. In stage III-IV cases (n = 270), diffuse abdominal carcinomatosis occurred in 62.1% of cases, while recurrences presented as a single lesion or multiple nodules occurred in 9.9% and 26.7% of cases, respectively. Pattern of recurrence as carcinomatosis was shown to be associated with unfavourable outcome even when stratified according to platinum free interval (PFI) duration. In multivariate analysis, pattern of recurrence and PFI duration retained an independent prognostic role for post-relapse survival. Duration of PFI and type of recurrence may independently influence post-relapse survival in ovarian cancer patients.
Authors:
Gabriella Ferrandina; Francesco Legge; Vanda Salutari; Amelia Paglia; Antonia Testa; Giovanni Scambia
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Publication Detail:
Type:  Journal Article     Date:  2006-08-09
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  42     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  2296-302     Citation Subset:  IM    
Affiliation:
Gynaecologic Oncology Unit, Catholic University of Rome, L.go A. Gemelli 8, 00168 Rome, Italy. gabriella.ferrandina@libero.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local / mortality,  pathology*
Ovarian Neoplasms / mortality,  pathology*,  surgery
Survival Analysis
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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