Document Detail

Impact of pancreatic leaks on survival following pancreaticoduodenectomy.
MedLine Citation:
PMID:  20442516     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Pancreatic leak following pancreaticoduodenectomy has a major impact on postoperative mortality. However, it is not clear whether pancreatic leaks affect long term survival in patients with pancreatic ductal adenocarcinoma. OBJECTIVE: The aim of this study is to compare the long term outcome in patients who underwent pancreaticoduodenectomy, with and without postoperative pancreatic leak. PATIENTS: All 133 patients who underwent a pancreaticoduodenectomy at the HepatoPancreatoBiliary Unit, Addenbrooke's Hospital, Cambridge, between June 2002 and June 2007 were identified from a prospectively held database. The study was restricted to 47 patients who had a confirmed diagnosis of pancreatic ductal adenocarcinoma. SETTING: Pancreatic leak was defined as drain fluid amylase more than three times the serum level for more than 3 days post operatively. MAIN OUTCOME MEASURE: Long term survival of patients with and without leaks were compared using Kaplan-Meier curves and significance was measured using the log-rank test. RESULTS: Median follow-up was 30.8 months. The median actuarial survival of all ductal adenocarcinoma patients was 19 months. Pancreatic leaks occurred in 9 patients (19.1%). There were no significant differences in the overall survival or presence of recurrence between the two groups. CONCLUSIONS: Pancreatic leak following pancreaticoduodenectomy does not appear to impact on long-term outcome of patients with pancreatic ductal adenocarcinoma.
Fabio Ausania; Natalie Cook; Neville Jamieson; Emanuel Huguet; Asif Jah; Raaj Praseedom
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Publication Detail:
Type:  Journal Article     Date:  2010-05-05
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  11     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-05     Completed Date:  2010-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  226-9     Citation Subset:  IM    
Hepato-Pancreato-Biliary Surgery, Addenbrooke's Hospital, NIHR Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.
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MeSH Terms
Adenocarcinoma, Mucinous / mortality,  surgery
Amylases / metabolism
Carcinoma, Pancreatic Ductal / mortality*,  surgery
Carcinoma, Papillary / mortality,  surgery
Cholangiocarcinoma / mortality,  surgery
Databases, Factual
Duodenal Neoplasms / mortality,  surgery
Follow-Up Studies
Kaplan-Meiers Estimate
Pancreatic Neoplasms / mortality*,  surgery
Pancreaticoduodenectomy / mortality*
Postoperative Complications / metabolism,  mortality*
Reg. No./Substance:
EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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