| Impact of nutritional status on the oral bioavailability of leucine administered to rats as part of a standard enteral diet. | |
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MedLine Citation:
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PMID: 21292362 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the absorption and relative bioavailability of leucine administered orally as part of an enteral diet in well and malnourished animals. METHODS: Two groups - RN (regular nutrition) and PCR (protein-calorie restricted) - were fed with different diets for 23-25 days. Rats from each group were assigned randomly to one of three treatments (water, T-Diet Plus Standard(®) (problem) or Isosource ST(®) (reference)) administered in single (N = 76) or multiple (N = 39) doses. Blood samples were assayed for leucine content. Area under the curve (AUC) was calculated by non-compartmental analysis. Log-transformed AUC(s) were statistically compared by analysis of variance, and 90% confidence intervals (CI 90%) of the ratio of the log-transformed AUC(s) between problem and reference diets, and between enteral diet and water were determined. RESULTS: The AUC (last) between the problem and reference diets was not statistically different. 90% CIs for single and multiple doses were 58.4-137.5% and 78-134.6% for RN and 76.7-172.2% and 72-167.2% for PCR, respectively. Leucine absorption was 12% higher among malnourished animals when multiple doses were administered, but the differences detected were not statistically different. CONCLUSIONS: In spite of the different composition of proteins in the enteral diets tested, the absorption of leucine, even though slightly higher in the malnourished state, is similar in both of them. |
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Authors:
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Silvia Miralles-Arnau; Amparo Nácher; Africa Jiménez; N Víctor Jiménez-Torres; Matilde Merino-Sanjuán |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: - ISSN: 1532-1983 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Valencia, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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