Document Detail

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development.
MedLine Citation:
PMID:  20424644     Owner:  NLM     Status:  MEDLINE    
Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.
B Desvoyes; M P Sanchez; E Ramirez-Parra; C Gutierrez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-28
Journal Detail:
Title:  Heredity     Volume:  105     ISSN:  1365-2540     ISO Abbreviation:  Heredity     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity     Country:  England    
Other Details:
Languages:  eng     Pagination:  80-91     Citation Subset:  IM    
Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, Madrid, Spain.
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MeSH Terms
Arabidopsis / genetics*,  growth & development*
Cell Proliferation
Epigenesis, Genetic*
Histones / metabolism*
Nucleosomes / metabolism*
Reg. No./Substance:
0/Histones; 0/Nucleosomes

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