| Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging. | |
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MedLine Citation:
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PMID: 21448965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. MATERIALS AND METHODS: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixel-wise pharmacokinetic parameters K(trans) , v(e) , and k(ep) were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ(2) -test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. RESULTS: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10(-7) ). Both K(trans) and k(ep) derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). CONCLUSION: The study demonstrated the impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs. |
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Authors:
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Junichi Tokuda; Hatsuho Mamata; Ritu R Gill; Nobuhiko Hata; Ron Kikinis; Robert F Padera; Robert E Lenkinski; David J Sugarbaker; Hiroto Hatabu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: 2011-08-09 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 968-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Harvard Medical School, Boston, MA, USA. tokuda@bwh.harvard.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Computer Graphics Contrast Media / pharmacology Diagnostic Imaging / methods Female Humans Image Processing, Computer-Assisted / methods* Kinetics Lung / pathology* Magnetic Resonance Imaging / methods* Male Middle Aged Motion Reproducibility of Results Respiration User-Computer Interface |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA067165/CA/NCI NIH HHS; P01 CA067165/CA/NCI NIH HHS; P01 CA067165-12/CA/NCI NIH HHS; P41 RR013218-13/RR/NCRR NIH HHS; P41 RR019703/RR/NCRR NIH HHS; P41 RR019703-06/RR/NCRR NIH HHS; P41RR-013218/RR/NCRR NIH HHS; R21 CA116271/CA/NCI NIH HHS; R21 CA116271-02/CA/NCI NIH HHS; U41 RR019703/RR/NCRR NIH HHS; U54 EB005149/EB/NIBIB NIH HHS; U54 EB005149-06/EB/NIBIB NIH HHS |
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Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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