Document Detail

Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging.
MedLine Citation:
PMID:  21448965     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization.
MATERIALS AND METHODS: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixel-wise pharmacokinetic parameters K(trans) , v(e) , and k(ep) were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ(2) -test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared.
RESULTS: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10(-7) ). Both K(trans) and k(ep) derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015).
CONCLUSION: The study demonstrated the impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.
Junichi Tokuda; Hatsuho Mamata; Ritu R Gill; Nobuhiko Hata; Ron Kikinis; Robert F Padera; Robert E Lenkinski; David J Sugarbaker; Hiroto Hatabu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  33     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-30     Completed Date:  2011-08-09     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Aged, 80 and over
Computer Graphics
Contrast Media / pharmacology
Diagnostic Imaging / methods
Image Processing, Computer-Assisted / methods*
Lung / pathology*
Magnetic Resonance Imaging / methods*
Middle Aged
Reproducibility of Results
User-Computer Interface
Grant Support
P01 CA067165/CA/NCI NIH HHS; P01 CA067165/CA/NCI NIH HHS; P01 CA067165-12/CA/NCI NIH HHS; P41 RR013218/RR/NCRR NIH HHS; P41 RR013218-13/RR/NCRR NIH HHS; P41 RR019703/RR/NCRR NIH HHS; P41 RR019703-06/RR/NCRR NIH HHS; P41RR-013218/RR/NCRR NIH HHS; R21 CA116271/CA/NCI NIH HHS; R21 CA116271/CA/NCI NIH HHS; R21 CA116271-02/CA/NCI NIH HHS; U41 RR019703/RR/NCRR NIH HHS; U54 EB005149/EB/NIBIB NIH HHS; U54 EB005149/EB/NIBIB NIH HHS; U54 EB005149-06/EB/NIBIB NIH HHS
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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