Document Detail

Impact of non-di-(2-ethylhexyl)phthalate cardiopulmonary bypass tubes on inflammatory cytokines and coagulation-fibrinolysis systems during cardiopulmonary bypass.
MedLine Citation:
PMID:  20035395     Owner:  NLM     Status:  MEDLINE    
Di-(2-ethylhexyl)phthalate (DEHP), an excellent plasticizer for poly(vinyl chloride) (PVC), is a known endocrine-disrupting chemical. This study was designed to investigate whether a new non-DEHP bilayer tube reduced the release of DEHP, suppressed inflammatory cytokines, and altered coagulation-fibrinolysis systems. Sixteen patients undergoing coronary artery bypass grafting (CABG) were randomly assigned to the non-DEHP bilayer group (group B, n = 8), or the noncoated PVC group (group N, n = 8). The level of DEHP in the blood was measured before and after cardiopulmonary bypass (CPB). The levels of interleukin-6 (IL-6), D-dimer, and thrombin-antithrombin complex (TAT) were also measured at six points during and after CPB. DEHP was significantly lower in group B (472 +/- 141 ng/ml) after CPB compared with group N (2094 +/- 1046 ng/ml). The IL-6 level was significantly lower in group B (151 +/- 131 pg/ml) than group N (206 +/- 224 pg/ml) 180 min after protamine administration. The D-dimer level was significantly lower in group B 60 min after protamine administration (6.2 +/- 2.4 microg/ml in group B vs 10.4 +/- 4.5 microg/ml in group N) and 180 min after protamine administration (4.4 +/- 0.7 microg/ml in group B vs 7.3 +/- 2.7 microg/ml in group N). Group B had a tendency toward reduced postoperative bleeding compared with group N at any time. The bilayer tube was superior to the noncoated tube in terms of the inhibition of DEHP release, inflammatory cytokines, and the fibrinolysis system.
Yosuke Takahashi; Toshihiko Shibata; Yasuyuki Sasaki; Hiromichi Fujii; Takeshi Ikuta; Yasuyuki Bito; Atsushi Nakahira; Shigefumi Suehiro
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-12-25
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  12     ISSN:  1619-0904     ISO Abbreviation:  J Artif Organs     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  IM    
Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.
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MeSH Terms
Antithrombin III
Cardiopulmonary Bypass / instrumentation*
Diethylhexyl Phthalate / adverse effects*,  blood
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinolysis / drug effects*
Interleukin-6 / blood*
Middle Aged
Peptide Hydrolases / blood
Plasticizers / adverse effects*,  analysis
Polyvinyl Chloride
Postoperative Hemorrhage / etiology*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Interleukin-6; 0/Plasticizers; 0/antithrombin III-protease complex; 0/fibrin fragment D; 117-81-7/Diethylhexyl Phthalate; 9000-94-6/Antithrombin III; 9002-86-2/Polyvinyl Chloride; EC 3.4.-/Peptide Hydrolases

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