| Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20120794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Multiple micronutrient supplements could increase hemoglobin and improve micronutrient status of pregnant women more than iron supplements alone or iron with folic acid. OBJECTIVE: To compare the effects of multiple micronutrients with those of iron supplements alone or iron with folic acid, on hemoglobin and micronutrient status of pregnant women. METHODS: Studies were identified in which pregnant women were randomized to treatment with multiple micronutrients, or with iron with or without folic acid. A pooled analysis was conducted to compare the effects of these supplements on maternal hemoglobin, anemia, and micronutrient status. Effect size was calculated for individual and combined studies, based on mean change from baseline to final measure in the group receiving iron, with or without folic acid, minus the mean change in the group, divided by the pooled standard deviation of the two groups. The effect on the relative risk of anemia or iron deficiency was calculated as the probability of anemia or iron deficiency in the group receiving multiple micronutrients divided by the probability in the group receiving iron, with or without folic acid. RESULTS: Multiple micronutrient supplements had the same impact on hemoglobin and iron status indicators as iron with or without folic acid. There was no overall effect on serum retinol or zinc. In the only study in which status of other micronutrients was analyzed, a high prevalence of multiple deficiencies persisted in the group receiving multiple micronutrients provided with daily recommended intakes of each nutrient. CONCLUSIONS: Multiple micronutrient supplements increased hemoglobin synthesis to the same extent as supplementation with iron with or without folic acid, although often they contained lower amounts of iron. The amount of supplemental iron and other nutrients that can enable pregnant women with micronutrient deficiencies to achieve adequate status remains to be determined. |
| | |
Authors:
|
Lindsay H Allen; Janet M Peerson; |
Related Documents
:
|
15797604 - Lipid metabolism in arbuscular mycorrhizal roots of medicago truncatula. 2531844 - Characterization of siderophores from ustilago maydis. 10901674 - Reducing degradation of azo dye by zero-valent iron in aqueous solution 7766914 - Mass spectral fragmentation patterns of some new 3,7-dichloro-benzo[1,2-b:4,5-b']dithio... 3597624 - Determination of some hydroxycholesterols in human serum samples. 18458974 - Unusual fatty acid isomers of triacylglycerols and polar lipids in female limpet gonads... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Food and nutrition bulletin Volume: 30 ISSN: 0379-5721 ISO Abbreviation: Food Nutr Bull Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-03-11 Revised Date: 2010-05-18 |
Medline Journal Info:
|
Nlm Unique ID: 7906418 Medline TA: Food Nutr Bull Country: Japan |
Other Details:
|
Languages: eng Pagination: S527-32 Citation Subset: IM |
Affiliation:
|
U.S. Department of Agriculture, ARS Western Human Nutrition Research Center, University of California, Davis, California, USA. Lindsay.allen@ars.usda.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Iron-Deficiency
/
prevention & control* Dietary Supplements* Female Folic Acid / administration & dosage* Folic Acid Deficiency / drug therapy, prevention & control Humans Iron / administration & dosage* Micronutrients / administration & dosage*, deficiency Nutritional Status* Pregnancy Pregnancy Complications / drug therapy, prevention & control* Prenatal Nutritional Physiological Phenomena* Randomized Controlled Trials as Topic Statistics as Topic |
| Chemical | |
Reg. No./Substance:
|
0/Micronutrients; 59-30-3/Folic Acid; 7439-89-6/Iron |
| Investigator | |
Investigator/Affiliation:
|
Pierre Adou / ; Victor M Aguayo / ; Lindsay H Allen / ; Zulfiqar Ahmed Bhutta / ; Parul Christian / ; Shaonong Dang / ; Gwenola Desplats / ; Michael Dibley / ; Shams El Arifeen / ; Caroline Fall / ; David Fisher / ; Henrik Friis / ; Exnevia Gomo / ; Batool Azra Haider / ; Adi Hidayat / ; Alan Jackson / ; Abbas Jahari / ; Pernille Kaestel / ; Patrick Kolsteren / ; Kusharisupeni / ; Aissa Mamadoultaibou / ; Dharma Sharna Mandandhar / ; Barrie Margetts / ; Clive Osmond / ; David Osrin / ; Lars Ake Persson / ; Usha Ramakrishnan / ; Dominique Roberfroid / ; Carine Ronsmans / ; Anuraj H Shankar / ; Subarkah / ; Sunawang / ; Budi Otomo / ; Anjana Vaidya / ; Hong Yan / ; Noel Zagre / ; Lingxia Zeng / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple micronutrient supplementation during pregnancy in low-income countries: review of methods a...
Next Document: Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of ...