| Impact of moderate exercise workload on predicted optimal AV and VV delays determined by an intracardiac electrogram-based method for optimizing cardiac resynchronization therapy. | |
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MedLine Citation:
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PMID: 20517697 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS: Aim of this study is to evaluate reproducibility, consistency and the impact of moderate exercise workload on optimized PV and VV delays as determined by the IEGM-based QuickOpt™ method (St. Jude Medical), that was shown to produce hemodynamic performance similar to that obtained by echo-guided aortic VTI maximization. METHODS: Sixty patients with CRT-ICD (65 ± 9 years, 12% female, LVEF 28 ± 9%, 48% CAD and 52% DCM) were enrolled. IEGM-based PV/VV optimization was conducted six times: twice at rest, twice immediately after a 6-min walk test and twice following a 3-min recovery period. Timing cycle delays were programmed in accordance with the optimization results. Follow-up was performed after 1 year. RESULTS: Although significant difference in heart rate was reached [68 ± 9 bpm (REST) vs. 79 ± 12 (6MWT), p < 0.001], differences were not observed between IEGM-based optimized PV/VV delays: PV(opt) = 128 ± 14 ms (REST) versus 130 ± 17 ms (6MWT) versus 129 ± 16 ms (RECOV); VV(opt) = 15 ± 24 ms (REST) versus 15 ± 22 ms (6MWT) versus 16 ± 24 ms (RECOV). During 1-year follow-up PV(opt) and VV(opt) remained stable (ΔPV(opt) = 10 ± 10 ms, ΔVV(opt) = 9 ± 11 ms). CONCLUSION: Optimized IEGM-based timing cycle delays are independent of moderate exercise status within a particular patient but varied between patients. This supports the use of PV/VV optimization in each CRT patient. |
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Authors:
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Margit Strauss; Torsten Becker; Thomas Kleemann; Ngoc Dyck; Frank Birkenhauer; Karlheinz Seidl |
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Publication Detail:
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Type: Journal Article Date: 2010-06-02 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 99 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 735-41 Citation Subset: IM |
Affiliation:
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Arrhythmia Center, Heart Center Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen, Germany. straussm@klilu.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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