| Impact milling of pharmaceutical agglomerates in the wet and dry states. | |
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MedLine Citation:
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PMID: 17804181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study focused on the milling of wet granulated agglomerates at points before and after drying in a typical high-shear pharmaceutical process train. These steps, referred to here as wet and dry milling, utilized a conical screen mill. Milling of granulation in the wet state eliminated 1-10mm size agglomerates without affecting granule porosity or inducing further agglomeration. These millimeter-size agglomerates broke down during wet milling into moderately sized fragments larger than 125microm. In contrast, when milled after drying, these same 1-10mm-size agglomerates broke down predominantly into fine particles less than 125microm. Data from screen-less milling trials suggest that the mill screen served only as a classifier and did not significantly contribute to the route of breakage for either wet or dry milling. However, in the case of dry milling, mill screens with grated surface textures did result in fewer fines than non-grated screens. This may be a result of reduced residence time in the mill. Experiments varying the size fraction of feed material and the rotational speed of the mill's impeller identified impact attrition as the primary mechanism governing dry granule breakage. The findings in this study shed light into the fundamental breakdown behavior of pharmaceutical agglomerates and demonstrate how breakdown of wet agglomerates via a de-lumping step prior to drying can lead to a reduced level of fine particle generation during dry milling. |
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Authors:
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Luke R Schenck; Russell V Plank |
Publication Detail:
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Type: Journal Article Date: 2007-07-27 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 348 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-04-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 18-26 Citation Subset: IM |
Affiliation:
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Pharmaceutical Technology, Merck & Co., Inc., West Point, PA 19486, USA. Luke_Schenck@Merck.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Carboxymethylcellulose / chemistry Cellulose / analogs & derivatives, chemistry Excipients / chemistry* Lactose / chemistry Mechanics Particle Size* Pharmaceutical Preparations / chemistry* Povidone / chemistry Powders / chemistry* Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Pharmaceutical Preparations; 0/Powders; 0/microcrystalline cellulose; 63-42-3/Lactose; 7732-18-5/Water; 9003-39-8/Povidone; 9004-32-4/Carboxymethylcellulose; 9004-34-6/Cellulose; 9004-64-2/hydroxypropylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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