| Impact of microcirculatory flow pattern changes on the development of acute edematous and necrotizing pancreatitis in rabbit pancreas. | |
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MedLine Citation:
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PMID: 7995190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impairment of pancreatic microcirculation has often been advocated as one pathogenic mechanism in necrotizing pancreatitis. In contrast, data on pancreatic capillary perfusion in edematous pancreatitis are scarce. It was the aim of this experimental study to compare changes in pancreatic microcirculation in edematous and necrotizing pancreatitis. Twelve rabbits were allocated to two groups. Two different models of acute pancreatitis were used. Edematous pancreatitis was elicited by intravenous administration of cerulein (25 micrograms/kg/hr) (N = 6). Necrotizing pancreatitis of the biliary type was induced by pressure-controlled intraductal infusion of a mixture of taurocholate, trypsin, and blood (N = 6). Pancreatic microcirculation was quantified by means of intravital microscopy assessing functional capillary density, blood cell velocity, and distribution of the plasma marker FITC-dextran 70. Systemic hemodynamics were maintained at baseline values by fluid administration. Regardless of edema or necrosis, pronounced extravasation of FITC-dextran was recorded in the early stage of pancreatitis. In cerulein-induced pancreatitis, hyperemia developed as indicated by an increase in blood cell velocity in the presence of homogeneous capillary perfusion. In contrast, a progressive reduction of the number of perfused capillaries was detected in necrotizing pancreatitis. In conclusion, pancreatic microvascular perfusion may be regarded as an important pathogenetic factor for the determination of acute pancreatitis. |
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Authors:
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E Klar; W Schratt; T Foitzik; H Buhr; C Herfarth; K Messmer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 39 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-17 Completed Date: 1995-01-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2639-44 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Caerulein Capillary Permeability / physiology Edema / etiology Ischemia / complications*, pathology Microcirculation / physiology Necrosis Pancreas / blood supply*, pathology Pancreatitis / etiology*, pathology, physiopathology Rabbits |
| Chemical | |
Reg. No./Substance:
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17650-98-5/Caerulein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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