Document Detail


Impact of metabolic syndrome on future cardiovascular events in patients with first acute myocardial infarction.
MedLine Citation:
PMID:  19609207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of metabolic syndrome (MetS) is increasing worldwide and patients with MetS have increased risk of cardiovascular events. Recent studies in different populations showed higher prevalences of MetS in patients with acute myocardial infarction (MI) and identified MetS as an independent predictor of future cardiac events. This study sought to determine the prevalence of MetS in patients with acute MI and investigate the impact of MetS on adverse cardiovascular events after acute MI. One hundred and eighty-eight patients (155 men, 33 women) admitted with first acute MI were enrolled into the study. Of the total patients, 80 (42.6%) patients were diagnosed with MetS according to the National Cholesterol Education Program Adult Treatment Panel III criteria with modifications for high blood pressure and high fasting plasma glucose. Kaplan-Meier curves showed that the cumulative event-free survival rates did not differ between the patients with and without MetS during a median follow-up period of 27.7 (min:14, max:42) months (P>0.05). On multivariate Cox regression analysis controlling for hypertension, diabetes mellitus, glucose, MetS, and waist-to-hip ratio, there was no association between the major adverse coronary events and the presence of MetS (P>0.05), whereas Killip class (relative risk: 2.853, 95% confidence interval: 1.606-5.070; P<0.001) was identified as the only independent predictor of long-term cardiovascular outcomes. This study shows that MetS has no effect on long-term prognosis after MI. However, Killip class was identified as an independent predictor of major cardiac events.
Authors:
Hatice Selcuk; Ahmet Temizhan; Mehmet Timur Selcuk; Taner Sen; Orhan Maden; Sebahat Tekeli; Ali Sasmaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  20     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  370-5     Citation Subset:  IM    
Affiliation:
Turkiye Yuksek Ihtisas Hospital Cardiology Department, Ankara, Turkey. haticsel@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / etiology*,  mortality
Female
Hospitalization
Humans
Kaplan-Meiers Estimate
Male
Metabolic Syndrome X / complications*,  mortality
Middle Aged
Myocardial Infarction / complications*,  mortality
Prevalence
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Turkey / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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