| Impact of menstrual and reproductive factors on breast cancer risk in Tunisia: a case-control study. | |
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MedLine Citation:
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PMID: 23377925 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This report examined the relationship between menstrual and reproductive factors and breast cancer risk. The case-control study was conducted on 400 women with histological confirmed breast cancer operated during the 2006-2009 period at Farhat Hached University Hospital, Sousse, Tunisia, and 400 cancer-free controls, aged 25-75 years. The menstrual and reproductive history was assessed using a structured questionnaire. Odds ratios (ORs), 95 % confidence intervals (CI) and a full confounding assessment, included in this analysis, were derived using logistic regression. A positive family history of breast cancer was associated with a significantly increased risk of breast cancer (OR = 5.15, 95 % CI 1.48-17.94). Significant risk reduction was found with later age at menarche (P = 0.02). There was an insignificant increase in risk with later age at menopause (≥51 years; OR = 1.87), later age at first live birth (≥26 years; OR = 1.76) and nulliparous women compared to parous women (OR = 2.35). An insignificant decrease in risk was observed with increasing parity number (≥3 delivery; OR = 0.86). A significantly reduced risk of breast cancer was found for those women whose lifetime duration of breastfeeding was 73-108 months and for those who breastfed for ≥109 months (P = 0.00). Our findings suggest that age at menarche and breastfeeding history have great effects on breast cancer risk among Tunisian women. |
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Authors:
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Awatef Msolly; Olfa Gharbi; Slim Ben Ahmed |
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Publication Detail:
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Type: Journal Article Date: 2013-02-02 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 30 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 480 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, CHU Farhat Hached, 4000, Sousse, Tunisia, awatefmsolly@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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