| Impact of medication nonadherence on hospitalizations and mortality in heart failure. | |
| | |
MedLine Citation:
|
PMID: 21807328 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Limited literature exists on the association between medication adherence and outcomes among patients with heart failure. METHODS AND RESULTS: We conducted a retrospective longitudinal cohort study of 557 patients with heart failure with reduced ejection fraction (HFrEF) (defined by EF <50%) in a large health maintenance organization. We used multivariable Cox proportional hazards models to assess the relationship between adherence (with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, and aldosterone antagonists) and the primary outcome of all-cause mortality plus cardiovascular hospitalizations. Mean follow-up time was 1.1 years. Nonadherence (defined as <80% adherence) was associated with a statistically significant increase in the primary outcome in the cohort overall (hazard ratio 2.07, 95% confidence interval 1.62-2.64; P < .0001). This association remained significant when all 3 classes of heart failure medications and the components of the composite end point were considered separately and when the adherence threshold was varied to 70% or 90%. CONCLUSIONS: Medication nonadherence was associated with an increased risk of all-cause mortality and cardiovascular hospitalizations in a community heart failure population. Further research is needed to define systems of care that optimize adherence among patients with heart failure. |
| | |
Authors:
|
Ashley A Fitzgerald; J David Powers; P Michael Ho; Thomas M Maddox; Pamela N Peterson; Larry A Allen; Frederick A Masoudi; David J Magid; Edward P Havranek |
Related Documents
:
|
12185958 - The use of vitamin supplements in self-medication. 7936818 - Peritoneal ventilation: an animal model of extrapulmonary ventilation in experimental a... 22132288 - Tracking residents through multiple residency programs: a different approach for measur... 21562298 - Osteopathic specialty board certification. 7435268 - Inspiratory facilitatory and inhibitory vagal influences during apnoea in rabbits. 12013088 - A survey of physicians' attitude and approach to hormone replacement therapy during men... |
Publication Detail:
|
Type: Journal Article Date: 2011-06-23 |
Journal Detail:
|
Title: Journal of cardiac failure Volume: 17 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
|
Languages: eng Pagination: 664-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiology, Denver VA Medical Center, Denver, Colorado; Division of Cardiology, University of Colorado Denver School of Medicine, Denver, Colorado. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors associated with patient delay in seeking care after worsening symptoms in heart failure pati...
Next Document: Peripheral adaptation mechanisms in physical training and cardiac rehabilitation: the case of a pati...