Document Detail

Impact of medication nonadherence on coronary heart disease outcomes. A critical review.
MedLine Citation:
PMID:  9308504     Owner:  NLM     Status:  MEDLINE    
A critical review of published literature was performed to assess the impact of medication adherence on morbidity and mortality among patients with or at risk for coronary artery disease and congestive heart failure. Twenty-one original research articles that met our inclusion criteria and related medication adherence to morbidity and mortality are summarized. No clinical trials that specifically tested the impact of a compliance-enhancing intervention on outcome in coronary heart disease were identified. Among 12 studies that compared hospitalization rates and mortality between adherers and nonadherers, 7 showed a significant relationship between medication adherence and outcomes. Three studies showed that adherence to placebo was associated with improved outcomes, suggesting that adherent behavior may be a marker of better prognosis or confers a protective effect on patients with coronary heart disease. Further study is necessary to determine whether adherent behavior can be taught and whether compliance-enhancing strategies improve outcomes in coronary heart disease.
M M McDermott; B Schmitt; E Wallner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  157     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1921-9     Citation Subset:  AIM; IM    
Division of General Internal Medicine, Northwestern University Medical School, Chicago, Ill., USA.
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MeSH Terms
Clinical Trials as Topic
Coronary Disease / drug therapy*,  mortality
Heart Failure / drug therapy,  mortality
Risk Factors
Treatment Outcome
Treatment Refusal* / statistics & numerical data
Comment In:
Arch Intern Med. 1998 Apr 13;158(7):808-9   [PMID:  9554689 ]
ACP J Club. 1998 Mar-Apr;128(2):53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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