| Impact of measuring fractional flow reserve on decision-making in the cath lab in a cohort of patients being considered for coronary revascularization. | |
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MedLine Citation:
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PMID: 20814047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Fractional flow reserve (FFR) is an accepted standard to detect the functional significance of coronary stenoses. Recent trials suggest that revascularization of moderate coronary stenoses can be safely deferred if the FFR is > or = 0.75 and FFR can be used to guide therapy in multivessel disease. AIM: In a cohort of patients with moderate angiographic coronary disease, we sought to examine the influence of FFR on lesion revascularization and the impact of multivessel FFR assessment on revascularization strategy. METHODS AND RESULTS: Patients with FFR measurements taken between April 2005 to October 2007 were included. Out of 300 cases performed in this time, 264 patients were included. Patients were 62 +/- 11 years and 1.3 +/- 0.54 vessels were examined per case. 92.7% of lesions with a FFR < 0.75 underwent revascularizati on an d 93% of lesions with a FFR > or = 0.75 had intervention deferred. FFR was 0.71 +/- 0.07 in the revascularization group (9 coronary artery bypass graft surgery, 64 percutaneous coronary interventions) and 0.86 +/- 0.06 in the deferred group (p < 0.001). Overall, 75% of patients avoided revascularization of at least one vessel on the basis of the FFR. CONCLUSIONS: Measurement of FFR is clinically useful with a high impact on clinical decision-making in the catheterization laboratory. FFR can be used to reclassify patients with multivessel stenoses, reducing the need for revascularization in the majority of cases. |
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Authors:
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Tim Lockie; Divaka Perera; Kalpa De Silva; Ian Webb; Suzanne Pattinson; Simon Redwood |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 22 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 413-6 Citation Subset: IM |
Affiliation:
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The Rayne Institute, 3rd Floor Lambeth Wing, St. Thomas' Hospital, KCL, London, SE1 7EH, United Kingdom. tim.lockie@gstt.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Coronary Angiography Coronary Stenosis / physiopathology*, radiography, therapy* Decision Making Female Fractional Flow Reserve, Myocardial / physiology* Heart Catheterization / methods* Heart Function Tests / methods* Humans Male Middle Aged Myocardial Revascularization / methods* Severity of Illness Index Stents |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
| Comments/Corrections | |
Comment In:
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J Invasive Cardiol. 2010 Sep;22(9):417-8
[PMID:
20814048
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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