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Impact of maternal vitamin A supplementation on the mother-infant pair in Brazil.
MedLine Citation:
PMID:  20842169     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND/OBJECTIVES: Vitamin A deficiency (VAD) is a major public health problem. The supplementation of lactating women could be an effective strategy to combat it. The objective of this study was to assess the impact of maternal vitamin A supplementation on the mother-infant pair.
SUBJECTS/METHODS: This was a double blind, placebo-controlled randomized clinical assay in which 33 women received 200 000 IU of vitamin A and 33 women received soy oil between 20th and 30th postpartum days. Maternal blood and milk samples were collected immediately before supplementation and 3 months after delivery, when blood was also collected from the babies. Retinol concentrations 0.70 μmol/l in serum and 1.05 μmol/l in milk were considered to indicate VAD.
RESULTS: Increase in serum retinol level was observed in the supplemented group compared with the pre-supplementation levels (1.05 and 1.17 μmol/l, respectively; P=0.026) and to the post-supplementation levels of the control group (1.02 μmol/l; P=0.032). Reduction in breast milk retinol was observed in the control group compared with the pre-supplementation levels (1.93 and 1.34 μmol/l, respectively; P<0.0001) and to the post-supplementation levels of the supplemented group (1.56 μmol/l; P=0.0003). There was significant difference in the prevalence of VAD in breast milk after supplementation, 55.6% (15/27) in the control group and 16.1% (5/31) in the supplemented group (P=0.002). VAD was present in 66.1% (39/59) of infants, with mean serum retinol levels of 0.64±0.30 μmol/l in the control group and of 0.69±0.26 μmol/l in the supplemented group.
CONCLUSIONS: Supplementation had a positive impact on maternal vitamin A status. No effect on infant status was detectable 2 months after supplementation with a single dose.
Authors:
T M Martins; I S Ferraz; J C Daneluzzi; C E Martinelli; L A Del Ciampo; R G Ricco; A A Jordão; M C Patta; H Vannucchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-15
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1302-7     Citation Subset:  IM    
Affiliation:
Faculty of Medicine of Ribeirão Preto, Department of Puericulture and Pediatrics, University of São Paulo, Ribeirão Preto, SP, Brazil.
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