| Impact of maternal vitamin A supplementation on the mother-infant pair in Brazil. | |
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MedLine Citation:
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PMID: 20842169 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Vitamin A deficiency (VAD) is a major public health problem. The supplementation of lactating women could be an effective strategy to combat it. The objective of this study was to assess the impact of maternal vitamin A supplementation on the mother-infant pair. SUBJECTS/METHODS: This was a double blind, placebo-controlled randomized clinical assay in which 33 women received 200 000 IU of vitamin A and 33 women received soy oil between 20th and 30th postpartum days. Maternal blood and milk samples were collected immediately before supplementation and 3 months after delivery, when blood was also collected from the babies. Retinol concentrations 0.70 μmol/l in serum and 1.05 μmol/l in milk were considered to indicate VAD. RESULTS: Increase in serum retinol level was observed in the supplemented group compared with the pre-supplementation levels (1.05 and 1.17 μmol/l, respectively; P=0.026) and to the post-supplementation levels of the control group (1.02 μmol/l; P=0.032). Reduction in breast milk retinol was observed in the control group compared with the pre-supplementation levels (1.93 and 1.34 μmol/l, respectively; P<0.0001) and to the post-supplementation levels of the supplemented group (1.56 μmol/l; P=0.0003). There was significant difference in the prevalence of VAD in breast milk after supplementation, 55.6% (15/27) in the control group and 16.1% (5/31) in the supplemented group (P=0.002). VAD was present in 66.1% (39/59) of infants, with mean serum retinol levels of 0.64±0.30 μmol/l in the control group and of 0.69±0.26 μmol/l in the supplemented group. CONCLUSIONS: Supplementation had a positive impact on maternal vitamin A status. No effect on infant status was detectable 2 months after supplementation with a single dose. |
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Authors:
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T M Martins; I S Ferraz; J C Daneluzzi; C E Martinelli; L A Del Ciampo; R G Ricco; A A Jordão; M C Patta; H Vannucchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 64 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1302-7 Citation Subset: IM |
Affiliation:
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Faculty of Medicine of Ribeirão Preto, Department of Puericulture and Pediatrics, University of São Paulo, Ribeirão Preto, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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