Document Detail


Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study.
MedLine Citation:
PMID:  20128938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The perinatal nutritional environment impacts upon the health and well-being of mother and child also in the long term. The aim of the present study was to determine the safety and efficacy of perinatal probiotic-supplemented dietary counselling by evaluating pregnancy outcome and fetal and infant growth during the 24 months' follow-up. Altogether, 256 women were randomised at their first trimester of pregnancy into a control and a dietary intervention group. The intervention group received intensive dietary counselling provided by a nutritionist and were further randomised, double-blind to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo). Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P = 0.003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P = 0.035 for birth weight and P = 0.028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable.
Authors:
Raakel Luoto; Kirsi Laitinen; Merja Nermes; Erika Isolauri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-04
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1792-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Turku University Hospital, Turku, Finland. raakel.luoto@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Bifidobacterium
Birth Weight*
Counseling
Diabetes, Gestational / prevention & control
Diet*
Dietary Supplements
Double-Blind Method
Female
Fetal Development* / drug effects
Humans
Infant, Newborn / growth & development*
Lactobacillus rhamnosus
Male
Maternal Nutritional Physiological Phenomena*
Obesity / etiology
Pregnancy
Pregnancy Outcome*
Pregnancy Trimester, First
Prenatal Care
Probiotics / adverse effects,  therapeutic use*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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