Document Detail

Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study.
MedLine Citation:
PMID:  20128938     Owner:  NLM     Status:  MEDLINE    
The perinatal nutritional environment impacts upon the health and well-being of mother and child also in the long term. The aim of the present study was to determine the safety and efficacy of perinatal probiotic-supplemented dietary counselling by evaluating pregnancy outcome and fetal and infant growth during the 24 months' follow-up. Altogether, 256 women were randomised at their first trimester of pregnancy into a control and a dietary intervention group. The intervention group received intensive dietary counselling provided by a nutritionist and were further randomised, double-blind to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo). Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P = 0.003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P = 0.035 for birth weight and P = 0.028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable.
Raakel Luoto; Kirsi Laitinen; Merja Nermes; Erika Isolauri
Related Documents :
8623818 - Pregnancy outcomes and health care use: effects of abuse.
20465798 - Pelvic girdle pain--associations between risk factors in early pregnancy and disability...
18485738 - Family planning and life planning reproductive intentions among individuals seeking rep...
11987878 - Exercise in pregnancy.
8907758 - Evaluation of reproductive function in turkana women with enzyme immunoassays of urinar...
20065308 - The unifying difference: dyadic coping with spontaneous abortion among religious jewish...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-04
Journal Detail:
Title:  The British journal of nutrition     Volume:  103     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1792-9     Citation Subset:  IM    
Department of Paediatrics, Turku University Hospital, Turku, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Birth Weight*
Diabetes, Gestational / prevention & control
Dietary Supplements
Double-Blind Method
Fetal Development* / drug effects
Infant, Newborn / growth & development*
Lactobacillus rhamnosus
Maternal Nutritional Physiological Phenomena*
Obesity / etiology
Pregnancy Outcome*
Pregnancy Trimester, First
Prenatal Care
Probiotics / adverse effects,  therapeutic use*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and...
Next Document:  How accurate are adolescents in portion-size estimation using the computer tool Young Adolescents' N...