| Impact of maternal nutrition on ovine foetoplacental development: A review of the role of insulin-like growth factors. | |
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MedLine Citation:
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PMID: 20434853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intrauterine environment may impact the conceptus (embryo/foetus and associated extra-embryonic membranes) during 'critical periods' of development, when rapid cell divisions occur in various tissues of the body, and may alter expression of the foetal genome, and this may have lifelong consequences; a phenomenon known as foetal programming. Among intrauterine environmental factors, nutrition appears to play the most critical role in influencing placental and foetal growth. Changes in maternal nutritional status during pregnancy often results in permanent structural and functional deficits in foetal, as well as, postnatal growth of animals. Maternal undernutrition or overnutrition during pregnancy can impair foetal growth. Alterations of the insulin-like growth factor cascade are speculated to play a significant role in intrauterine nutrition-associated compromised foetal growth and foetal programming. Insulin-like growth factors, IGF-1 and IGF-2 are nutritionally sensitive proteins that are believed to modulate foetal and placental growth. The role of these growth factors in nutrition-associated deficits in ovine foetal and placental growth is the subject of this review. |
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Authors:
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U M Igwebuike |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-04-13 |
Journal Detail:
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Title: Animal reproduction science Volume: 121 ISSN: 1873-2232 ISO Abbreviation: Anim. Reprod. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7807205 Medline TA: Anim Reprod Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Veterinary Anatomy, University of Nigeria, Nsukka, Nigeria. abuchi2002@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena
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physiology* Animals Female Fetal Development / physiology* Insulin-Like Growth Factor I / physiology Insulin-Like Growth Factor II / physiology Maternal Nutritional Physiological Phenomena / physiology* Placenta / growth & development* Pregnancy Sheep / embryology*, physiology Somatomedins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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