Document Detail

Impact of maternal influenza vaccination during pregnancy on the incidence of acute respiratory illness visits among infants.
MedLine Citation:
PMID:  17146026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether influenza vaccination of pregnant women prevents visits for respiratory illness in their infants born during the influenza season. DESIGN: Retrospective matched cohort study. SETTING: Four managed care organizations in the United States. Patients A total of 41 129 infants (3160 and 37 969 born to vaccinated and unvaccinated mothers, respectively) born between 1995 and 2001. Main Exposure Maternal influenza vaccination. Infants were considered exposed if their gestational age at birth was at least 30 weeks, if the time from maternal vaccination to birth was at least 28 days, and if they were exposed to at least 14 days of the influenza season. MAIN OUTCOME MEASURES: Incidence of acute respiratory illnesses (outpatient, emergency department, and inpatient settings combined) and incident rate ratios (IRRs) for infants exposed and unexposed to maternal vaccination during the following 4 periods: peak influenza, respiratory syncytial virus predominant, periseasonal, and summer weeks. The time to the first acute respiratory illness during peak influenza weeks was also assessed. RESULTS: During the peak influenza weeks, infant visit rates were 15.4 and 17.1 per 100 person-months for exposed and unexposed infants, respectively (IRR, 0.90; 95% confidence interval, 0.80-1.02). Adjusted IRRs for the 4 periods found a protective effect of infant female sex, whereas Medicaid status and maternal high-risk status increased infant visit rates. Maternal influenza vaccination did not reduce visit rates during any of the 4 time periods (IRR for peak influenza season, 0.96; 95% confidence interval, 0.86-1.07) and did not delay the onset of first respiratory illness. CONCLUSION: We were unable to demonstrate that maternal influenza vaccination reduces respiratory illness visit rates among their infants.
Eric K France; Renae Smith-Ray; David McClure; Simon Hambidge; Stanley Xu; Kristi Yamasaki; David Shay; Eric Weintraub; Alicia M Fry; Steve B Black; Henry R Shinefield; John P Mullooly; Lisa A Jackson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  160     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-05     Completed Date:  2007-01-05     Revised Date:  2007-06-29    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1277-83     Citation Subset:  AIM; IM    
Department of Preventive Medicine and Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80231, USA.
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MeSH Terms
Infant, Newborn
Influenza Vaccines*
Influenza, Human / prevention & control
Pregnancy Complications, Infectious / prevention & control
Proportional Hazards Models
Respiratory Tract Infections / epidemiology,  prevention & control*
Retrospective Studies
Reg. No./Substance:
0/Influenza Vaccines
Comment In:
Arch Pediatr Adolesc Med. 2007 Jun;161(6):618   [PMID:  17548774 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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