Document Detail

Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits.
MedLine Citation:
PMID:  24901657     Owner:  NLM     Status:  In-Data-Review    
The concept of Developmental Origins of Health and Disease initially stemmed from the developmental programming of metabolic diseases. Reproductive functions and fertility in adulthood may also be programmed during foetal development. We studied the impact of dietary-induced maternal hyperlipidaemia and hypercholesterolaemia (HH), administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Male rabbits born to HH dams and fed a control diet had significantly lighter testes and epididymes compared with rabbits born to control dams at adulthood. No significant changes in sperm concentration, sperm DNA integrity and sperm membrane composition were observed, but serum-free testosterone concentrations were decreased in HH males. This study confirms the importance of maternal metabolic status for the development of male reproductive organs.
C Dupont; D Ralliard-Rousseau; A Tarrade; C Faure; M Dahirel; B Sion; F Brugnon; R Levy; P Chavatte-Palmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of developmental origins of health and disease     Volume:  5     ISSN:  2040-1752     ISO Abbreviation:  J Dev Orig Health Dis     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517692     Medline TA:  J Dev Orig Health Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
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