Document Detail


Impact of maternal endothelial nitric oxide synthase gene polymorphisms on blood pressure, protein excretion and fetal outcome in pregnancy.
MedLine Citation:
PMID:  18463669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A genetic association study was conducted to assess whether genetically determined alterations of the nitric oxide system are associated with clinical markers of pre-eclampsia. A large number of Caucasian women were consecutively included after delivery and genotyped for the endothelial nitric oxide synthase gene (NOS3) polymorphisms G894T, T789C (n=1502) and intron 4a/b (n=2186). There are no significant differences in mean blood pressure (BP), protein excretion or new-onset peripheral oedema between any of the genotypes over the course of pregnancy. Neither particular haplotypes nor the combined presence of any two alleles is associated with those markers of pre-eclampsia. The maternal polymorphisms do not seem to influence fetal growth, birth weight or the incidence of congenital malformations. We demonstrate in a large Caucasian population that maternal polymorphisms of the NOS3 gene are not related to clinical markers of pre-eclampsia. The functional relevance of the NOS3 variants alone does not seem to be strong enough to affect BP regulation during pregnancy.
Authors:
B Hocher; Y-P Chen; S Hügle; J Repey; K Krause; T Slowinski; M Godes; E Schaeffeler; F Guthmann; R Wauer; H Halle; G Gossing; T Pfab
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-08
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  641-7     Citation Subset:  IM    
Affiliation:
Center for Cardiovascular Research/Institute of Pharmacology, Charité Campus Mitte, Berlin, Germany. berthold.hocher@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology*
Female
Humans
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Genetic*
Pre-Eclampsia / genetics*
Pregnancy
Pregnancy Outcome*
Proteinuria / urine*
Chemical
Reg. No./Substance:
EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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