Document Detail

Impact of maternal endothelial nitric oxide synthase gene polymorphisms on blood pressure, protein excretion and fetal outcome in pregnancy.
MedLine Citation:
PMID:  18463669     Owner:  NLM     Status:  MEDLINE    
A genetic association study was conducted to assess whether genetically determined alterations of the nitric oxide system are associated with clinical markers of pre-eclampsia. A large number of Caucasian women were consecutively included after delivery and genotyped for the endothelial nitric oxide synthase gene (NOS3) polymorphisms G894T, T789C (n=1502) and intron 4a/b (n=2186). There are no significant differences in mean blood pressure (BP), protein excretion or new-onset peripheral oedema between any of the genotypes over the course of pregnancy. Neither particular haplotypes nor the combined presence of any two alleles is associated with those markers of pre-eclampsia. The maternal polymorphisms do not seem to influence fetal growth, birth weight or the incidence of congenital malformations. We demonstrate in a large Caucasian population that maternal polymorphisms of the NOS3 gene are not related to clinical markers of pre-eclampsia. The functional relevance of the NOS3 variants alone does not seem to be strong enough to affect BP regulation during pregnancy.
B Hocher; Y-P Chen; S Hügle; J Repey; K Krause; T Slowinski; M Godes; E Schaeffeler; F Guthmann; R Wauer; H Halle; G Gossing; T Pfab
Related Documents :
21504429 - Low penetrance and effect on protein secretion of lgi1 mutations causing autosomal domi...
24409999 - Versatile strategy for isolating transcription activator-like effector nuclease-mediate...
21476119 - Genetic testing and parkinson disease: assessment of patient knowledge, attitudes, and ...
21439709 - The spectrum of nlrp7 mutations in french patients with recurrent hydatidiform mole.
21388369 - Dihydrofolate reductase mutations-associated megaloblastic anemia and cerebral folate d...
8744539 - Recent advances in the molecular genetics of hypertension.
20874489 - Genetic risk markers for nasopharyngeal carcinoma in portugal: tumor necrosis factor al...
21504429 - Low penetrance and effect on protein secretion of lgi1 mutations causing autosomal domi...
19432979 - Tracking the global dispersal of a cosmopolitan insect pest, the peach potato aphid.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-08
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  641-7     Citation Subset:  IM    
Center for Cardiovascular Research/Institute of Pharmacology, Charité Campus Mitte, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / physiology*
Nitric Oxide Synthase Type III / genetics*
Polymorphism, Genetic*
Pre-Eclampsia / genetics*
Pregnancy Outcome*
Proteinuria / urine*
Reg. No./Substance:
EC Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endothelium-dependent vasodilation in conduit and resistance vessels in relation to the endothelial ...
Next Document:  Sympathetic nerve hyperactivity of essential hypertension is lower in postmenopausal women than men.