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Impact of maternal characteristics on fetal growth in the third trimester of pregnancy. A population-based study.
MedLine Citation:
PMID:  22302307     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the ultrasound examination and birth. Analyses were performed using multivariate linear and polynomial regression analyses. Results. Positive associations were found between maternal body mass index (BMI), height, preexisting diabetes mellitus, and a high fetal growth, whereas maternal smoking had a negative impact. In the univariate analyses, primiparity and grand multiparity (≥4 previous children) were significantly associated with a reduced fetal growth, but in the multivariate analysis, no association between parity and fetal growth could be detected. Both the univariate and the multivariate analyses revealed a significant inverse u-shaped association between maternal age and fetal growth. Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre-existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Gun Lindell; Karel Maršál; Karin Källén
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Clinical Sciences Lund, Lund University, Lund, Sweden. gun.lindell@med.lu.se.
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