Document Detail

Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study.
MedLine Citation:
PMID:  18477013     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effects of breastfeeding and probiotics on infant sensitization still remain discrepant. OBJECTIVE: To explore probable explanatory factors in infant sensitization and the protective effect of probiotics. METHODS: Altogether 171 mother-infant pairs from an ongoing placebo-controlled double-blind study with nutrition modulation by dietary counselling and probiotic supplementation were studied. Skin prick testing was done in infants at 6 and 12 months and in mothers at third trimester of pregnancy. The breast milk concentrations of cytokines TGF-beta2, soluble CD14, IFN-gamma, TNF-alpha, IL-10, IL-6, IL-4 and IL-2 were measured. RESULTS: The risk of sensitization increased in infants with allergic mothers breastfeeding over 6 months [odds ratio (OR=4.83, P=0.005)], or exclusively breastfeeding over 2.5 months (OR=3.4, P=0.018). Probiotic supplementation had a protective effect against sensitization in infants with a high hereditary risk due to maternal sensitization (OR=0.3, P=0.023). The concentration of TGF-beta2 tended to be higher in the colostrum of the mothers in the probiotic group as compared with those on placebo (probiotic/placebo ratio=1.50, P=0.073). A similar result was obtained in the subgroup of allergic mothers (probiotic/placebo ratio=1.56, P=0.094). CONCLUSION: Infants of atopic mothers, specifically when breastfed exclusively over 2.5 months or totally over 6 months, had a higher risk of sensitization at the age of 12 months. This risk could be reduced by the use of probiotics during pregnancy and lactation, partly by resulting in a beneficial composition of the breast milk.
A Huurre; K Laitinen; S Rautava; M Korkeamäki; E Isolauri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-05-08
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  38     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-10-22     Revised Date:  2009-01-22    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1342-8     Citation Subset:  IM    
Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland.
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MeSH Terms
Breast Feeding*
Cytokines / analysis
Dietary Supplements*
Double-Blind Method
Hypersensitivity, Immediate / diet therapy*,  epidemiology,  prevention & control*
Infant, Newborn
Milk, Human / chemistry,  immunology
Probiotics / therapeutic use*
Skin Tests
Reg. No./Substance:
Comment In:
Clin Exp Allergy. 2008 Oct;38(10):1698; author reply 1698-9   [PMID:  18721254 ]

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