| Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. | |
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MedLine Citation:
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PMID: 18477013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of breastfeeding and probiotics on infant sensitization still remain discrepant. OBJECTIVE: To explore probable explanatory factors in infant sensitization and the protective effect of probiotics. METHODS: Altogether 171 mother-infant pairs from an ongoing placebo-controlled double-blind study with nutrition modulation by dietary counselling and probiotic supplementation were studied. Skin prick testing was done in infants at 6 and 12 months and in mothers at third trimester of pregnancy. The breast milk concentrations of cytokines TGF-beta2, soluble CD14, IFN-gamma, TNF-alpha, IL-10, IL-6, IL-4 and IL-2 were measured. RESULTS: The risk of sensitization increased in infants with allergic mothers breastfeeding over 6 months [odds ratio (OR=4.83, P=0.005)], or exclusively breastfeeding over 2.5 months (OR=3.4, P=0.018). Probiotic supplementation had a protective effect against sensitization in infants with a high hereditary risk due to maternal sensitization (OR=0.3, P=0.023). The concentration of TGF-beta2 tended to be higher in the colostrum of the mothers in the probiotic group as compared with those on placebo (probiotic/placebo ratio=1.50, P=0.073). A similar result was obtained in the subgroup of allergic mothers (probiotic/placebo ratio=1.56, P=0.094). CONCLUSION: Infants of atopic mothers, specifically when breastfed exclusively over 2.5 months or totally over 6 months, had a higher risk of sensitization at the age of 12 months. This risk could be reduced by the use of probiotics during pregnancy and lactation, partly by resulting in a beneficial composition of the breast milk. |
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Authors:
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A Huurre; K Laitinen; S Rautava; M Korkeamäki; E Isolauri |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-05-08 |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 38 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2008-10-22 Revised Date: 2009-01-22 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 1342-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Turku University Central Hospital and University of Turku, Turku, Finland. anu.huurre@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Feeding* Cytokines / analysis Dietary Supplements* Double-Blind Method Female Humans Hypersensitivity, Immediate / diet therapy*, epidemiology, prevention & control* Infant Infant, Newborn Milk, Human / chemistry, immunology Mothers Pregnancy Probiotics / therapeutic use* Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
| Comments/Corrections | |
Comment In:
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Clin Exp Allergy. 2008 Oct;38(10):1698; author reply 1698-9
[PMID:
18721254
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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