Document Detail

Impact of margin size on the predicted risk of radiogenic second cancers following proton arc therapy and volumetric modulated arc therapy for prostate cancer.
MedLine Citation:
PMID:  23154795     Owner:  NLM     Status:  MEDLINE    
We previously determined that the predicted risk of radiogenic second cancer in the bladder and rectum after proton arc therapy (PAT) was less than or equal to that after volumetric modulated arc therapy (VMAT) with photons, but we did not consider the impact of margin size on that risk. The current study was thus conducted to evaluate margin size's effect on the predicted risks of second cancer for the two modalities and the relative risk between them. Seven treatment plans with margins ranging from 0 mm in all directions to 6 mm posteriorly and 8 mm in all other directions were considered for both modalities. We performed risk analyses using three risk models with varying amounts of cell sterilization and calculated ratios of risk for the corresponding PAT and VMAT plans. We found that the change in risk with margin size depended on the risk model but that the relative risk remained nearly constant with margin size, regardless of the amount of cell sterilization modeled. We conclude that while margin size influences the predicted risk of a second cancer for a given modality, it appears to affect both modalities in roughly equal proportions so that the relative risk between PAT and VMAT is approximately equivalent.
Laura A Rechner; Rebecca M Howell; Rui Zhang; Wayne D Newhauser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-15
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-03     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  N469-79     Citation Subset:  IM    
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MeSH Terms
Middle Aged
Monte Carlo Method
Neoplasms, Radiation-Induced / etiology*
Neoplasms, Second Primary / etiology*
Prostatic Neoplasms / radiotherapy*
Proton Therapy / adverse effects*
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated / adverse effects*
Grant Support
1 R01 CA131463-01A1/CA/NCI NIH HHS; K07CA131505/CA/NCI NIH HHS; R01 CA131463/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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