|Impact of male obesity on semen quality and serum sex hormones.|
|Jump to Full Text|
|PMID: 22190919 Owner: NLM Status: In-Data-Review|
|Introduction. To investigate the association of high Body Mass Index (BMI) with semen parameters and reproductive hormones in men of reproductive age. Setting. The Saudi Center for Assisted Reproduction. Method. This study was conducted during the period from February 2009 to February 2011. Subjects were exposed through medical history evaluation as well as physical examination. BMI was calculated. Two semen samples about 1 week apart were taken from each participant by masturbation after 2-5 days of abstinence. The samples were assessed according to the WHO Criteria. Blood samples (5 ml) were withdrawn; centrifuged and the resulting sera were preserved at -4 degrees Centigrade. Serum FSH, LH, PRL, and Testosterone levels were estimated by the ELISA method. Results. There was no significant correlation between BMI and any of semen and hormonal parameters. There was significant negative correlation between age and total motility. Only the advanced paternal age has shown significant association with low motility (P = 0.007). Conclusion. Our study showed a significant effect of aging on sperm motility and concentration.|
|Mamdoh Eskandar; Manal Al-Asmari; Suresh Babu Chaduvula; Mesfer Al-Shahrani; Mohammed Al-Sunaidi; Mona Almushait; Osman Donia; Suliman Al-Fifi|
Related Documents :
|10095169 - Long-term follow-up of an infant with thyrotoxicosis due to germline mutation of the ts...
1658459 - Ontogeny of the thymus gland of a marsupial (monodelphis domestica).
8919629 - Kininogenase secretion from dispersed cells of mouse submandibular gland.
24315809 - Molecular monitoring of the bacterial community structure in foal feces pre- and post-w...
23930639 - Influence of age and vertical facial type on the location of the mandibular foramen.
9002919 - A pilot study comparing three salivary collection methods in an adult population with s...
8441729 - Influence of a novel oxy-halogen compound on early growth and nitrogen retention of bro...
22143179 - Age-associated decrease of sirt1 expression in rat hippocampus prevention by late onset...
15827359 - Instruction of jump-landing technique using videotape feedback: altering lower extremit...
|Type: Journal Article Date: 2011-11-30|
|Title: Advances in urology Volume: 2012 ISSN: 1687-6377 ISO Abbreviation: Adv Urol Publication Date: 2012|
|Created Date: 2011-12-22 Completed Date: - Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 101476240 Medline TA: Adv Urol Country: Egypt|
|Languages: eng Pagination: 407601 Citation Subset: -|
|Department of Obstetrics and Gynecology and Reproductive Medicine, College of Medicine, King Khalid University, P.O. Box 641, Abha 61321, Saudi Arabia.|
|APA/MLA Format Download EndNote Download BibTex|
Journal ID (nlm-ta): Adv Urol
Journal ID (publisher-id): AU
Publisher: Hindawi Publishing Corporation
Copyright © 2012 Mamdoh Eskandar et al.
Received Day: 26 Month: 6 Year: 2011
Revision Received Day: 11 Month: 10 Year: 2011
Accepted Day: 12 Month: 10 Year: 2011
Print publication date: Year: 2012
Electronic publication date: Day: 30 Month: 11 Year: 2011
Volume: 2012E-location ID: 407601
PubMed Id: 22190919
|Impact of Male Obesity on Semen Quality and Serum Sex Hormones|
|Suresh Babu Chaduvula1|
1Department of Obstetrics and Gynecology and Reproductive Medicine, College of Medicine, King Khalid University, P.O. Box 641, Abha 61321, Saudi Arabia
2Department of Obstetrics and Gynecology, Abha General Hospital, Abha, Saudi Arabia
3Department of Pediatrics Endocrinology, College of Medicine, King Khalid University, Abha 61321, Saudi Arabia
|Correspondence: *Mamdoh Eskandar: firstname.lastname@example.org
[other] Academic Editor: Robert E. Brannigan
Obesity is considered now as an epidemic disease that is rapidly progressing in developed and underdeveloped world. The effects of obesity not only relate to chronic medical conditions but also have been strongly related to reproductive problems [1, 2]. Potential effects of increased body mass index (BMI) in men on male fertility have not been subjected to the same degree of research as female obesity. There is growing evidence over the years that suggests a trend towards deterioration in semen quality in relation to obesity . Several hypotheses have been proposed, and male obesity was suggested as a strong factor. Several studies have linked male obesity to poor semen quality and male infertility [4, 5]. The mechanisms that explain the relation between obesity and male infertility are not fully understood. Higher DNA fragmentation indexes in obese males , increased oxidative stress , and hormonal imbalance  have been suggested as possible mechanisms of obesity-associated subfertility. The aim of this study is to evaluate the effect of male obesity on semen quality and hormonal milieu.
This is a retrospective study conducted at the Saudi Center for Assisted Reproduction, Abha, Saudi Arabia during the period from February 2009 to February 2011. A total of 500 males were recruited, those who were seeking fertility treatment in our IVF center. Local institute approval was taken before starting the study. Informed consents were taken from participating patients.
Subjects were exposed to medical history evaluation as well as physical and systemic examination. Exclusion criteria included apparent genital infection, uncontrolled diabetes mellitus, uncontrolled hypertension, severe cerebrovascular or cardiovascular disease, and alcohol or drug abuse. BMI was calculated as the weight in kilograms divided by the square of height in meters. Height and weight are measured using the same scale for all participants.
Two semen samples about a week apart were taken from each participant by masturbation after 2–5 days of abstinence. The samples were assessed by 2 experienced personnel according to the WHO criteria .Venous blood samples (5 mL) were withdrawn from each subject and centrifuged and the resulting sera were preserved at −4 degree centigrade. Serum FSH, LH, PRL, and testosterone levels were estimated by the ELISA method (Diagnostics Systems Laboratories, Webster, Tex, USA).
Data were expressed as mean standard deviation (SD), median, percentage, and range. Comparison between groups was made by Mann-Whitney test. Correlation between different variables was made using Spearman‘s rank correlation. Multiple regression was used to analyze the relation between different values. P < 0.05 was considered as significant. MedCalc program was used for analysis.
Five hundred males participated in the study. The characteristics of subjects are shown in Table 1. When subjects were classified into 2 groups based on BMI of <30 or >30, there was no significant difference between the 2 groups in any of the semen or hormonal parameters. These data are shown in Table 2.
There was no significant correlation between BMI and any of semen and hormonal parameters. There was significant negative correlation between age and total motility (CC = −0.138) and with a significant P value of 0.002. Table 3 shows the correlation among different parameters which were insignificant.
Several clinical and hormonal variables were entered in multiple regression analysis to detect relation to semen concentration. Only the age and sperm concentration showed significant association with a P value of 0.007. This data is shown in Table 4.
The present study did not reveal any relation between BMI and any of semen or hormonal parameters of the studied population. This contradicts several studies which documented a deleterious effect of obesity on semen quality both in normal fertile [10, 11] and subfertile males [12, 13]. However, there are several recent reports that support our findings. In one meta-analysis, no relation between BMI and semen parameters was found . Another study of healthy obese partners of subfertile couples failed to identify any relation between BMI and semen parameters . Others suggested no effect of birth weight, childhood BMI, or adult BMI on semen quality . It appears that this point is far from being settled. It needs larger studies with adequate control of confounders to reach a solid conclusion. Our study showed a significant effect of aging on sperm motility and concentration. There was a strong significant negative correlation of age and total motility percentage. Moreover, age was significantly associated with sperm concentration in the multiple regression model. These findings are supported with other studies which suggest deleterious effect of age on semen quality. One study documented a significant effect of age on all semen parameters . It has also been suggested that the age of the patient is intimately related to a decrease of the number of sperms, with the decrease of the number of motile forms and the increase of the nonmotile . This study adds to the opinion denying an effect of male obesity on semen quality or hormonal milieu.
|1.||Must A,Spadano J,Coakley EH,Field AE,Colditz G,Dietz WH. The disease burden associated with overweight and obesityJournal of the American Medical AssociationYear: 1999282161523152910546691|
|2.||Clark AM,Thornley B,Tomlinson L,Galletley C,Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatmentHuman ReproductionYear: 1998136150215059688382|
|3.||Swan SH,Elkin EP,Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934–1996Environmental Health PerspectivesYear: 20001081096196611049816|
|4.||Jensen TK,Andersson AM,Jørgensen N,et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish menFertility and SterilityYear: 200482486387015482761|
|5.||Hofny ERM,Ali ME,Abdel-Hafez HZ,et al. Semen parameters and hormonal profile in obese fertile and infertile malesFertility and SterilityYear: 201094258158419423100|
|6.||Evenson DP,Jost LK,Marshall D,et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinicHuman ReproductionYear: 19991441039104910221239|
|7.||Kodama H,Yamaguchi R,Fukuda J,Kasai H,Tanaka T. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patientsFertility and SterilityYear: 19976835195249314926|
|8.||Hammoud AO,Gibson M,Peterson CM,Meikle AW,Carrell DT. Impact of male obesity on infertility: a critical review of the current literatureFertility and SterilityYear: 200890489790418929048|
|9.||WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus InteractionYear: 19994th editionCambridge, UKCambridge University Press|
|10.||Koloszár S,Daru J,Kereszturi A,Zavaczki Z,SzölloSi J,Pál A. Effect of female body weight on efficiency of donor AIArchives of AndrologyYear: 200248532332712230817|
|11.||Stewart TM,Liu DY,Garrett C,Jørgensen N,Brown EH,Baker HWG. Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm outputHuman ReproductionYear: 20092471561156819351657|
|12.||Nguyen RHN,Wilcox AJ,Skjærven R,Baird DD. Men’s body mass index and infertilityHuman ReproductionYear: 20072292488249317636282|
|13.||Hammoud AO,Wilde N,Gibson M,Parks A,Carrell DT,Meikle AW. Male obesity and alteration in sperm parametersFertility and SterilityYear: 20089062222222518178190|
|14.||MacDonald AA,Herbison GP,Showell M,Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysisHuman Reproduction UpdateYear: 2009163293311 Article ID dmp047.. 19889752|
|15.||Duits FH,Van Wely M,Van Der Veen F,Gianotten J. Healthy overweight male partners of subfertile couples should not worry about their semen qualityFertility and SterilityYear: 20109441356135919608174|
|16.||Ramlau-Hansen CH,Hansen M,Jensen CR,Olsen J,Bonde JP,Thulstrup AM. Semen quality and reproductive hormones according to birthweight and body mass index in childhood and adult life: two decades of follow-upFertility and SterilityYear: 201094261061819328465|
|17.||Paasch U,Grunewald S,Kratzsch J,Glander HJ. Obesity and age affect male fertility potentialFertility and SterilityYear: 20109472898290120667533|
|18.||Cánovas Ivorra JA,Cadenas García VP,Molina Gasset R,Fernández García JS,Sánchez Díaz AF,García Zamora JA. Relationship between male age and semen quality. Experience at the number 14 health-care area of the Valencia health-care agencyArchivos Espanoles de UrologiaYear: 200861670571018705192|
Previous Document: Clinical results after high-dose intensity-modulated radiotherapy for high-risk prostate cancer.
Next Document: Focus issue on male infertility.