| Impact of luminal density on plaque classification by CT coronary angiography. | |
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MedLine Citation:
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PMID: 20820922 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Non-invasive coronary CT angiography (CCTA) has the potential to characterize the composition of non-calcified coronary plaques. CT-density values characterized by Hounsfield Units (HU) may classify non-calcified plaques as fibrous or lipid-rich, but the luminal density caused by the applied contrast material influences HU in the plaques in vitro. The influence of luminal density on HU in non-calcified plaques in vivo is unknown. Hence the purpose of this study was to test whether plaque characterization by CCTA in vivo depends on luminal density. Two CCTA-scans using two different contrast protocols were obtained from 14 male patients with coronary artery disease. The two contrast protocols applied resulted in high and low luminal density. Eleven non- calcified and 13 calcified plaques were identified and confirmed by intravascular ultrasound. Luminal attenuation differed with the two contrast protocols; 326[284;367] vs. 118[103;134] HU (P < 0.00001). In non-calcified plaques mean HU-values was lower 48[28;69] vs. 11[-4;25] HU (P = 0.004) with the low density protocol. As a consequence three out of eleven non-calcified plaques (27%) were reclassified from fibrous (high) to lipid rich (low). For calcified plaques a less pronounced but still significant difference in HU-values was found with the low luminal density. 770[622;919] vs. 675[496;855] HU (P = 0.02). Conclusion: Non-calcified plaques can be identified and classified by CCTA. However, the luminal density affects the absolute HU of both non-calcified and calcified plaques. Characterization and classification of non-calcified plaques by absolute CT values therefore requires standardization of contrast protocols. |
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Authors:
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Maiken Glud Dalager; Morten Bøttcher; Gratien Andersen; Jesper Thygesen; Erik Morre Pedersen; Lone Dejbjerg; Ole Gøtzsche; Hans Erik Bøtker |
Publication Detail:
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Type: Journal Article Date: 2010-09-05 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 27 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 593-600 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgårdsvej 100, 8200, Aarhus N, Denmark, maikendalager@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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