| Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation. | |
| | |
MedLine Citation:
|
PMID: 16950168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-density lipoprotein (HDL) cholesterol has protective cardiovascular effects. We investigated the effect of baseline HDL cholesterol on the outcomes of patients who underwent drug-eluting stent implantation for acute coronary syndrome. Since March 2003, 1,032 consecutive patients were, according to their baseline HDL cholesterol level, included in a low HDL cholesterol group (n = 550, <40 mg/dl in men, <45 mg/dl in women, mean 32 +/- 7) or a high HDL cholesterol group (n = 482, >40 mg/dl in men, >45 mg/dl in women, mean 55 +/- 19). End points were death, Q-wave myocardial infarction, target lesion revascularization, and a composite of major adverse cardiac events at 30 days and 1 year. We assessed the relation between HDL cholesterol and end points. Patients with low HDL cholesterol more often had diabetes, a higher body mass index, higher triglyceride levels, and lower total cholesterol levels. Low-density lipoprotein cholesterol and statin treatment (98% in the 2 groups) were comparable. Incidences of mortality and major adverse cardiac events at 30 days were higher in the low than in the high HDL cholesterol group (p <0.001 and p = 0.002, respectively; chi-square analysis). At 1 year, more deaths occurred in the low HDL cholesterol group (p <0.001; chi-square analysis), as did major adverse cardiac events (p <0.001; chi-square analysis). Multivariate analysis showed low HDL cholesterol at baseline (hazard ratio 2.61, 95% confidence interval 1.33 to 5.12) to be a key predictor of major adverse cardiac events and death (hazard ratio 3.33, 95% confidence interval 1.15 to 10.0) at 1 year. In conclusion, regardless of baseline low-density lipoprotein cholesterol levels and statin therapy, additional strategies to increase HDL cholesterol should be evaluated in patients with acute coronary syndrome. |
| | |
Authors:
|
Roswitha M Wolfram; H Bryan Brewer; Zhenyi Xue; Lowell F Satler; Augusto D Pichard; Kenneth M Kent; Ron Waksman |
Related Documents
:
|
9794118 - Life-style factors associated with changes in serum lipids in a follow-up study of card... 2076138 - The national cholesterol education program: guidelines and commentaries. 2436408 - Serum lipoproteins in middle-aged men with psoriasis. 14561898 - Impaired plasma viscosity via increased cholesterol levels in peripheral occlusive arte... 929628 - Chromosome studies on bone marrow cells of chinese hamsters fed a radiosterilized diet. 12691168 - Post-genomic opportunities for understanding nutrition: the nutritionist's perspective. |
Publication Detail:
|
Type: Journal Article Date: 2006-07-17 |
Journal Detail:
|
Title: The American journal of cardiology Volume: 98 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-09-04 Completed Date: 2006-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 711-7 Citation Subset: AIM; IM |
Affiliation:
|
The Division of Cardiology, Washington Hospital Center, Washington, DC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Transluminal, Percutaneous Coronary Cholesterol, HDL / blood* Cholesterol, LDL / blood Coronary Disease / pathology, therapy Electrocardiography* Female Hospitalization Humans Male Middle Aged Myocardial Infarction / blood, mortality, physiopathology, therapy* Retreatment Stents* Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Probing the structure of Lhca3 by mutation analysis.
Next Document: Effect of diabetes mellitus on five-year clinical outcomes after single-vessel coronary stenting (a ...