Document Detail

Impact of long-term oral iron supplementation in breast-fed infants.
MedLine Citation:
PMID:  17785896     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To weigh benefits of oral iron supplements on infant's growth against its potential hazards. METHODS: 248 exclusively breast-fed infants aged 4-6 months were consecutively enrolled and divided into treatment group given iron containing multivitamin (TG = 198) and control group (placebo, PG = 50) given the same multivitamin but without is subdivided according to clinical assessment into group A (well nourished) and group B (malnourished); both were further stratified according to basal blood iron status. Assessment was done after 6 and 12 months with concurrent collection of morbidity parameters (diarrhea and fever). Data were normalized and analyzed using SPSS and Eurogrowth softwares. RESULTS: After 6 months treatment, weight and length gain was better in TG compared to placebo especially evident in anemic malnourished infants (P 0.05). Morbidity risk was linked to immunologic background of infant; odds ratio for diarrhea and fever was higher in malnourished compared to well nourished (P 0.05) or iron therapy (P for well-nourished non-anemic treatment vs PG > 0.05). CONCLUSION: Oral iron supplementation resulted in better effects on growth velocity of breast fed infants especially those who were initially malnourished and anemic or at least iron depleted, with less marked morbidity than in iron replete infants.
Nabil Abdelrazik; Mohammad Al-Haggar; Hala Al-Marsafawy; Hesham Abdel-Hadi; Rizk Al-Baz; Abdel-Hamid Mostafa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  74     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-09-28     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
Pediatrics Department, Faculty of Medicine, Mansoura University Children Hospital, Egypt.
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MeSH Terms
Administration, Oral
Analysis of Variance
Anemia, Iron-Deficiency / drug therapy*,  epidemiology
Breast Feeding*
Chi-Square Distribution
Egypt / epidemiology
Iron / administration & dosage*,  adverse effects
Nutritional Status
Prospective Studies
Treatment Outcome
Reg. No./Substance:

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