Document Detail

Impact, logistics and prospects of traditional prenatal diagnosis.
MedLine Citation:
PMID:  2689008     Owner:  NLM     Status:  MEDLINE    
Traditional second trimester prenatal diagnosis (PD) by amniocentesis was introduced about 20 years ago. It is still the most frequently used procedure for this purpose. About 85% of all requests for PD are based on maternal age alone. The commonest indication is a maternal age of 35 or higher at delivery. Attempts are being made to improve utilization of the limited laboratory capacity by evaluating the indication for PD by combining age and other indicators, ie. maternal-serum-alpha-fetoprotein and unconjugated estriol. Chorionic villus sampling so far has appealed to an additional group of pregnant women rather than being a replacement for the older procedure. While the impact of PD on the individual woman and her family is great, it has limited impact on the prevalence of Down syndrome patients in the society. Of major concern is the impact of PD on the attitude to a pregnancy with a possibly affected child, on the attitude to induced abortion in general and on the acceptance of disabled individuals. The importance of proper genetic counseling including ethical issues is stressed.
W Furhmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical genetics     Volume:  36     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  378-85     Citation Subset:  IM    
Institute of Human Genetics, Justus-Liebig-Universität Giessen, FRG.
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MeSH Terms
Amniocentesis / statistics & numerical data,  trends*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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