Document Detail

Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures.
MedLine Citation:
PMID:  20571794     Owner:  NLM     Status:  MEDLINE    
This work proposes a novel approach for enhancing the yield of lovastatin in Aspergillus terreus cultures by exploiting linoleic acid-derived signalling molecules, which are potentially involved in fungal cell-cell communication. High-performance liquid chromatography analysis revealed that production of lovastatin was enhanced up to 1.8-fold upon exogenous addition of the oxylipin precursor linoleic acid to low cell density cultures of A. terreus. Real-time PCR analysis showed that supplementation of linoleic acid also resulted in an increase in transcriptional levels of lovastatin biosynthetic genes lovB and lovF, indicating a transcriptional control of fatty acids (linoleic acid) on these genes in A. terreus. This study therefore demonstrates for the first time the potential of an oxylipin molecule as an enhancer of a fungal secondary metabolite production with positive impact for industrial exploitation.
Flavia Sorrentino; Ipsita Roy; Tajalli Keshavarz
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Publication Detail:
Type:  Journal Article     Date:  2010-06-23
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  88     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Applied Biotechnology Research Group, Department of Molecular and Applied Biosciences, School of Life Sciences, University of Westminster, 115 New Cavendish Street, W1W 6UW, London, UK.
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MeSH Terms
Aspergillus / metabolism*
Chromatography, High Pressure Liquid
Culture Media / chemistry*
Gene Expression Profiling
Linoleic Acid / metabolism*
Lovastatin / metabolism*
Polyketide Synthases / biosynthesis
Polymerase Chain Reaction
Transcription, Genetic
Reg. No./Substance:
0/Culture Media; 0/lovastatin nonaketide synthase, Aspergillus terreus; 2197-37-7/Linoleic Acid; 75330-75-5/Lovastatin; 79956-01-7/Polyketide Synthases

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