| Impact of left bundle branch block and activation pattern on the heart. | |
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MedLine Citation:
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PMID: 18570622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left bundle branch block (LBBB) is known to impair the mechanical function of the left ventricle. For a better understanding of the impact of LBBB on the structure and function of the heart and how this influences the management and outcome in patients with heart failure, we reviewed the most pertinent articles published from 1950 to 2007. Epidemiological studies identified LBBB as an independent risk factor for cardiac mortality. It is not only the morphology or duration of QRS but also the underlying myocardial pathology, ejection fraction or New York Heart Association class that may determine the clinical implications of LBBB. Data indicate that LBBB inversely affects the perfusion, systolic, diastolic performance and hemodynamics of the heart. However, there is no solid evidence answering the question of whether LBBB is a predictor, cause or consequence of myocardial dysfunction. Further studies are warranted for better understanding of these relationships, as this will allow better selection of patients and optimal time for resynchronization therapy in patients with LBBB. |
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Authors:
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Ayman A El-Menyar; Sayed M Abdou |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 6 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-23 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 843-57 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Cardiovascular Surgery, HMC, PO Box 3050, Doha, State of Qatar. elmenyar@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bundle-Branch Block
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complications,
physiopathology* Clinical Trials as Topic Coronary Circulation Diastole Electrocardiography* Heart Failure / etiology, mortality, physiopathology* Hemodynamics Humans Systole Ventricular Remodeling |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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