| IMPACT OF L-NAME ON THE CARDIOPULMONARY REFLEX IN CARDIAC HYPERTROPHY. | |
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MedLine Citation:
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PMID: 21865544 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is evidence that in cardiac failure there is defective baroreceptor reflex control of sympathetic nerve activity. Often, cardiac failure is preceded by a state of cardiac hypertrophy where there may be enhanced performance of the heart. This study investigated whether in two different models of cardiac hypertrophy there was an increased contribution of NO to the low pressure baroreceptor regulation of renal sympathetic nerve activity (RSNA) and nerve-dependent excretory function. Administration of a volume load, 0.25% bwt/min saline for 30 min, in normal rats decreased RSNA by 40% and increased urine flow by some 9 fold. Following L-NAME administration, 10 μg/kg/min for 60 min, which had no effect on blood pressure, heart rate or RSNA, the volume load induced renal sympatho-inhibitory and excretory responses were markedly enhanced. In cardiac hypertrophy states induced by two weeks isoprenaline/caffeine or one week thyroxine administration, the volume challenge failed to supress RSNA and there were blunted increases in urine flow in the innervated kidneys but following L-NAME infusion, the volume load decreased RSNA by 30-40% and increased urine flow by some 20 fold in the innervated kidneys, roughly to the same extent as observed in normal rats. These findings suggest that the blunted renal sympatho-inhibition and nerve-dependent diuresis to the volume load in cardiac hypertrophy are related to a heightened production or activity of NO within either the afferent or central arms of the reflex. |
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Authors:
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Maria M Buckley; Edward J Johns |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-24 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University College Cork. |
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