| Impact of the introduction of integrated PET-CT into the preoperative staging pathway of patients with potentially operable oesophageal carcinoma. | |
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MedLine Citation:
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PMID: 18555034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To retrospectively evaluate the role of integrated positron emission tomography computed tomography (PET-CT) in oesophageal carcinoma staging, in predicting prognosis and its influence on surgical management. MATERIALS AND METHODS: Twenty-five consecutive patients with potentially operable, biopsy-proven oesophageal malignancy who undergoing PET-CT from September 2004 to April 2007 were included in this study. Chi-square and Fisher's exact tests were used to compare the accuracy of N staging with PET-CT and CT/endoscopic ultrasound (EUS) using postoperative loco-regional nodal histology as the reference standard. The prognostic value of primary tumour maximum standardized uptake value (SUVmax) was derived using logistic regression. RESULTS: Seventeen men and eight women with a mean age of 62 years were studied. All tumours showed abnormal 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) uptake. Fifteen patients underwent surgical resection. There was high concordance between N staging at CT/EUS (14/15) and final histology. PET-CT N staging was discordant with final nodal histology in over half of the patients (8/15). PET-CT detected occult metastases in three patients (12%) that were not identified on CT and new synchronous tumours in two patients (8%). Patient management was altered in 10 patients (40%) as a direct result of PET-CT. No statistically significant association was observed between SUVmax and clinical outcome (p=0.65). CONCLUSION: Integrated PET-CT has a significant incremental value over conventional staging investigations mainly in the detection of distant metastases and synchronous tumours and frequently impacts on patient management. |
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Authors:
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H M Salahudeen; A Balan; K Naik; S Mirsadraee; A F Scarsbrook |
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Publication Detail:
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Type: Journal Article Date: 2008-04-11 |
Journal Detail:
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Title: Clinical radiology Volume: 63 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 765-73 Citation Subset: IM |
Affiliation:
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Department of Radiology, Leeds General Infirmary, St George Street, Leeds LS1 3EX, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology,
radionuclide imaging,
surgery Adult Aged Carcinoma / pathology*, radionuclide imaging*, surgery Carcinoma, Squamous Cell / pathology, radionuclide imaging, surgery Esophageal Neoplasms / pathology*, radionuclide imaging*, surgery Female Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Neoplasm Staging / methods Positron-Emission Tomography / methods* Preoperative Care Prognosis Radiopharmaceuticals / diagnostic use Retrospective Studies Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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