| Impact of intravenous immunoglobulin infusion on longitudinal left ventricular performance in patients with acute Kawasaki disease of usual course. | |
| | |
MedLine Citation:
|
PMID: 19632519 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PURPOSE: To determine the acute change in cardiac performance after intravenous immunoglobulin infusion (IVIG) in patients with acute Kawasaki disease (KD). MATERIALS AND METHODS: Subjects were 33 patients with KD who were treated with IVIG 2 g/kg and recovered without coronary artery lesion and 27 controls. Subjects underwent combined two-dimensional, Doppler, and tissue Doppler echocardiographic (TDI) studies. In KD, these echocardiographic studies were performed before IVIG, 48 h after IVIG, and in convalescence. Echocardiographic variables were compared between KD and controls as well as among 3 time points in KD. RESULTS: Before IVIG, KD showed significantly higher peak aortic velocity and shorter aortic ejection time as results of tachycardia and significantly lower E' (p<0.04) but significantly higher E/E' (p<0.02). After IVIG, patients with KD became afebrile and showed significantly lower TDI indices such as S', E', and, A' and isovolumic acceleration (IVA) (163+/-56 vs. 208+/-70 cm/s(2), p<0.01) with higher TDI-derived Tei index (0.50+/-0.10 vs. 0.44+/-0.06, p<0.02) than controls. These differences tended to disappear in convalescence. In analysis of repeated measurements, except for hemodynamic changes associated with tachycardia, S' (7.9+/-1.3 vs. 7.0+/-1.1 vs. 7.4+/-0.9 cm/s, p<0.001), IVA (227+/-72 vs. 163+/-56 vs. 180+/-63, p<0.05), and A' (7.7+/-3.0 vs. 5.6+/-1.3 vs. 6.7+/-2.3 cm/s, p<0.001) were significantly different among these time points. CONCLUSIONS: In patients with acute KD with usual course, IVIG induced transient sub-clinical longitudinal left ventricular dysfunction. |
| | |
Authors:
|
Yusuke Koteda; Kenji Suda; Shintaro Kishimoto; Shinichi Ito; Yoshiyuki Kudo; Hiroshi Nishino; Haruka Ishii; Motofumi Iemura; Toyojiro Matuishi |
Related Documents
:
|
11343139 - Coronary blood flow assessed by transthoracic echocardiography in neonates. 6192419 - Doppler echocardiographic studies in sequential atrioventricular pacing. 10325709 - Left ventricular diastolic function in congenital myotonic dystrophy. 8415219 - Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (mela... 8798099 - Changes in left ventricular filling during follow-up study in survivors and nonsurvivor... 2076269 - Diabetic heart muscle disease. 20351399 - Coronary artery occlusion and myocardial infarction caused by vasospasm within a myocar... 15389239 - Routine intravascular ultrasound scanning guidance of coronary stenting is not associat... 8922919 - Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-29 |
Journal Detail:
|
Title: Journal of cardiology Volume: 54 ISSN: 1876-4738 ISO Abbreviation: J Cardiol Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
|
Languages: eng Pagination: 45-51 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictors of no-reflow after percutaneous coronary intervention for culprit lesion with plaque rupt...
Next Document: Effect of pioglitazone on left ventricular diastolic function and fibrosis of type III collagen in t...