Document Detail

Impact of interval versus steady state exercise on nitric oxide production in patients with left ventricular dysfunction.
MedLine Citation:
PMID:  19476115     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the present study was to assess the impact of the interval exercise training (IET) vs. steady state exercise training (SSET) on nitric oxide production, through changes of circulating blood markers of endothelial function, including stable end-products of nitric oxide (NOx) and S-nitrosothiols (RSNOs) in patients with left ventricular dysfunction (LVD). PATIENTS AND METHODS: The impact of the IET vs. SSET on NOx and RSNOs production was assessed in a total of 31 (25 male, 6 female) patients with LVD (ejection fraction <40%), who were admitted to our residential rehabilitation centre. Patients were randomised into an IET group (n=18; 15 min interval exercise sessions, 2 times daily) and an SSET group (n=13; 5-10 min steady state exercise sessions, 2 times daily), and exercised every day over a period of 3 weeks. The modified Saville-Griess method was used to determine NOx and RSNOs concentrations. RESULTS: A significant increase was observed both for NOx (P < 0.05) and RSNOs (P < 0.001) in the IET group, as well as for RSNOs in the SSET group (P < 0.001). Both training methods were observed to significantly improve exercise capacity, as demonstrated for increased workload (P < 0.001 and P < 0.05 for the IET and SSET groups, respectively) and duration (P < 0.001 and P < 0.01 for the IET and SSET groups, respectively) of the exercise stress test at the end of the study. CONCLUSION: The results of the present study have demonstrated an increased nitric oxide production and improved exercise capacity in patients with left ventricular dysfunction, who were engaged in an interval exercise programme for three weeks, and clearly indicated an advantage of interval compared to steady state training method for cardiovascular rehabilitation.
Marina Deljanin Ilic; Stevan Ilic; Gordana Lazarevic; Gordana Kocic; Radmila Pavlovic; Vladisav Stefanovic
Related Documents :
923025 - Effect of digitalis on left ventricular function in exercising dogs.
11686505 - Diagnosis of anthracycline-induced late cardiomyopathy by exercise-spiroergometry and s...
6216815 - Morphometry of right ventricular hypertrophy induced by strenuous exercise in rat.
3443125 - The effect of training on the physical working capacity of mi patients with left ventri...
10231175 - Quantitative abdominal aortic flow measurements at controlled levels of ergometer exerc...
2213295 - An evaluation of sensory changes and pain relief in trigeminal neuralgia following intr...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cardiologica     Volume:  64     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Institute of Cardiology, Niska Banja, Faculty of Medicine, University of Nis, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood*
Exercise Test
Exercise Therapy / methods*
Exercise Tolerance / physiology*
Follow-Up Studies
Heart Ventricles / physiopathology,  ultrasonography
Middle Aged
Nitric Oxide / biosynthesis*,  blood
S-Nitrosothiols / blood
Stroke Volume / physiology*
Time Factors
Ventricular Dysfunction, Left / blood,  physiopathology,  rehabilitation*
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Biological Markers; 0/S-Nitrosothiols; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Non-invasive tissue Doppler imaging pulmonary capillary wedge pressure measurement improves NT-proBN...
Next Document:  Comparison of intracoronary adenosine and isosorbide dinitrate on no-reflow/slow flow during rotatio...