| Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. | |
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MedLine Citation:
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PMID: 16690156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: (1) To evaluate the diagnostic value of integrated positron emission and computed tomography (PET/CT) in comparison with contrast-enhanced CT (ceCT) to detect biliary tract tumors and associated distant and regional lymph node metastases and (2) to evaluate the impact of PET/CT on therapy management. METHODS: From January 2001 to March 2005, each patient who was treated for a malignancy of the biliary tract underwent PET/CT examination in addition to the standard work-up imaging. Data were prospectively collected and analyzed in comparison with ceCT. RESULTS: Sixty-one patients with malignancies of the biliary tract were included into the study. Diagnosis was proven in all patients either by histology or cytology. PET/CT detected all gallbladder cancers (n=14). PET/CT and ceCT provided a comparable accuracy for the primary intra- (n=14) and extra-hepatic cholangiocarcinomas (n=33). All distant metastases (12/12) were detected by PET/CT, but only 3/12 by ceCT (p<0.001). Regional lymph node metastases were detected by PET/CT and ceCT in only 12% vs. 24%. PET/CT findings resulted in a change of management in 17% of patients deemed resectable after standard work-up. CONCLUSIONS: PET/CT is particularly valuable in detecting unsuspected distant metastases which are not diagnosed by standard imaging. Thus, PET/CT staging has an important impact on selection of adequate therapy. |
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Authors:
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Henrik Petrowsky; Peer Wildbrett; Daniela B Husarik; Thomas F Hany; Simona Tam; Wolfram Jochum; Pierre-Alain Clavien |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-04-19 |
Journal Detail:
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Title: Journal of hepatology Volume: 45 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 43-50 Citation Subset: IM |
Affiliation:
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Swiss HPB (Hepato-Pancreato-Biliary) Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bile Duct Neoplasms / pathology*, radiography, radionuclide imaging Bile Ducts, Extrahepatic* Bile Ducts, Intrahepatic* Cholangiocarcinoma / pathology*, radiography, radionuclide imaging Female Gallbladder Neoplasms / pathology*, radiography, radionuclide imaging Humans Male Middle Aged Neoplasm Staging Positron-Emission Tomography Recurrence Reproducibility of Results Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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