| Impact of integrated PET/CT in the staging of oesophageal cancer: a UK population-based cohort study. | |
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MedLine Citation:
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PMID: 19520214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To document the impact of integrated positron-emission tomography and computed tomography (PET/CT) on the management of a cohort of UK patients undergoing PET/CT as part of their staging investigations for potentially curable oesophageal cancer. MATERIALS AND METHODS: A multicentre, prospective study of newly diagnosed patients with oesophageal cancer undergoing PET/CT was set up across five cancer networks covering a total population of 6.6 million. Data were prospectively collected for cases diagnosed between 1 November 2006 and 31 October 2007. RESULTS: One hundred and ninety-one patients underwent PET/CT, with 31 (16%) positive for possible metastatic disease. Amongst the 31 positive examinations, 18 (9.4%) were confirmed to have metastatic disease, and 13 (6.5%) patients had no subsequent evidence of metastatic disease, although in three (1.6%) of these a second previously unsuspected pathology was diagnosed. Two patients had false-negative PET/CT and were found to have metastatic disease. The results of the PET/CT examination down-staged 10 (5%) patients thought to have coeliac/M1a node involvement on CT. Fifteen of 110 (13%) patients with stage 3 or 4 disease at CT and endoscopic ultrasound (EUS) had confirmed metastatic disease at PET/CT, compared with none of 18 with stage 2b, three of 52 (6%) with stage 2a, and none of 10 with stage 1 disease. CONCLUSION: This study confirms the role of PET/CT in a multicentre UK setting in the management of patients with potentially curable carcinoma of the oesophagus, improving the accuracy of pre-treatment staging compared with CT and EUS alone. Early tumours infrequently show evidence of metastasis on PET/CT, although further data are required to confidently determine the stage of tumours where PET/CT has no additional value. |
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Authors:
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F Noble; D Bailey; ; K Tung; J P Byrne |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2009-05-26 |
Journal Detail:
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Title: Clinical radiology Volume: 64 ISSN: 1365-229X ISO Abbreviation: Clin Radiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-12 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 699-705 Citation Subset: IM |
Affiliation:
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Department of Surgery, Southampton University Hospital, Southampton, Hampshire, UK. fergus.noble@btinternet.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma*
/
pathology,
radiography,
radionuclide imaging Adult Aged Carcinoma, Squamous Cell* / pathology, radiography, radionuclide imaging England Esophageal Neoplasms / pathology, radiography*, radionuclide imaging Female Humans Male Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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