| Impact of the initial levels of laboratory variables on survival in chronic dialysis patients. | |
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MedLine Citation:
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PMID: 8840944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Besides the age at start of dialysis and the presence of diabetes mellitus, serum albumin has been shown to be a significant predictor of survival in prevalent dialysis patients. However, this was not evaluated in incipient dialysis patients. The initial biochemical variables were retrieved for a large dialysis population (N = 1,982) who were started on chronic dialysis in Okinawa, Japan from 1971 to 1990. Biochemical data that included blood urea nitrogen, serum creatinine, serum electrolytes (sodium, potassium, calcium, and phosphate), total cholesterol, triglyceride, total protein, serum albumin, and hematocrit obtained just before the first dialysis session were available for 1,491 (75.2%) patients. Six hundred sixty-four (43.2%) patients died by the end of 1993. Cox proportional analysis adjusted for sex, age, year of start of dialysis, presence of diabetes mellitus, and the laboratory variables was performed to examine the significance of the initial biochemical data on survival. The risk ratio was 0.577 (P = 0.0025) in serum albumin, 1.291 (P = 0.0138) in serum potassium, and 0.966 (P = 0.0202) in serum sodium. The study results support the notion that nutritional status is important for survival in chronic dialysis patients. Causes of hypoalbuminemia, hyperkalemia, and hyponatremia should be evaluated carefully at initiation of dialysis. |
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Authors:
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K Iseki; H Uehara; K Nishime; K Tokuyama; K Yoshihara; K Kinjo; Y Shiohira; K Fukiyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 28 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-25 Completed Date: 1996-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 541-8 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, University of The Ryukyus, Okinawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Humans Infant Male Middle Aged Potassium / blood Prognosis Proportional Hazards Models Renal Dialysis / mortality* Serum Albumin / analysis Sodium / blood Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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