| Impact of inflammation on brain volume in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 22232347 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To study changes in brain volume measured monthly in patients treated for relapsing multiple sclerosis due to loss of tissue and the appearance of inflammation. Design and Patients The results from T2/fluid-attenuated inversion recovery axial images from 13 consecutive monthly 3-T brain magnetic resonance imaging tests conducted on 74 patients diagnosed with relapsing multiple sclerosis in the BECOME study were used to calculate whole brain volumes using automated software analysis tools. The patients had been randomized to receive treatment with interferon beta-1b or glatiramer acetate. Ongoing inflammation was studied by counting the number of combined active lesions and measuring the volume of gadolinium enhancement. A mixed-effects model was used to analyze brain volumes over time. RESULTS: There was a significant decrease in brain volume over time but there was no difference in its rate of change by age, sex, frequency of ongoing inflammation, multiple sclerosis type, or randomized treatment assignment. The mean rate of brain volume change per month from multivariable models was -1.1 cm(3) (95% CI, -1.5 to -0.6) and during times of magnetic resonance imaging activity, it increased transiently by an average of 1.2 cm(3)/lesion (95% CI, 0.7 to 1.7) and 7.1 cm(3)/1 cm(3 )of gadolinium volume. In a model with both measures, combined active lesions were independent predictors of brain volume but gadolinium volume was not. CONCLUSION: Two major changes in brain volume occur in patients with relapsing multiple sclerosis, a steady decrease likely due to tissue loss with overlapping transient increases due to the appearance of inflammation. |
| | |
Authors:
|
Jojy Cheriyan; Soyeon Kim; Leo J Wolansky; Stuart D Cook; Diego Cadavid |
Related Documents
:
|
7502737 - The neuroradiologist's contribution to stereotactic neuro-radio-surgery. 21893957 - Meningioangiomatosis in a 5-year-old boy presenting with intractable seizures. 16015497 - Laser surface registration for lateral skull base surgery. 1995537 - Stereotactic target point verification of an x ray and ct localizer. 19472637 - Assessment of trabecular bone microarchitecture by two different x-ray microcomputed to... 16129797 - Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of neurology Volume: 69 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 82-8 Citation Subset: AIM; IM |
Affiliation:
|
MS Clinical Development Group, Biogen Idec, 14 Cambridge Center, Bldg 6A, 6th floor, Cambridge, MA 02142. cadavidi@umdnj.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Daclizumab use in patients with pediatric multiple sclerosis.
Next Document: Large, nonplateauing relationship between clinical disability and cerebral white matter lesion load ...