| Impact of in-scanner head motion on multiple measures of functional connectivity: Relevance for studies of neurodevelopment in youth. | |
| | |
MedLine Citation:
|
PMID: 22233733 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It has recently been reported (Van Dijk et al., 2011) that in-scanner head motion can have a substantial impact on MRI measurements of resting-state functional connectivity. This finding may be of particular relevance for studies of neurodevelopment in youth, confounding analyses to the extent that motion and subject age are related. Furthermore, while Van Dijk et al. demonstrated the effect of motion on seed-based connectivity analyses, it is not known how motion impacts other common measures of connectivity. Here we expand on the findings of Van Dijk et al. by examining the effect of motion on multiple types of resting-state connectivity analyses in a large sample of children and adolescents (n=456). Following replication of the effect of motion on seed-based analyses, we examine the influence of motion on graphical measures of network modularity, dual-regression of independent component analysis, as well as the amplitude and fractional amplitude of low frequency fluctuation. In the entire sample, subject age was highly related to motion. Using a subsample where age and motion were unrelated, we demonstrate that motion has marked effects on connectivity in every analysis examined. While subject age was associated with increased within-network connectivity even when motion was accounted for, controlling for motion substantially attenuated the strength of this relationship. The results demonstrate the pervasive influence of motion on multiple types functional connectivity analysis, and underline the importance of accounting for motion in studies of neurodevelopment. |
| | |
Authors:
|
Theodore D Satterthwaite; Daniel H Wolf; James Loughead; Kosha Ruparel; Mark A Elliott; Hakon Hakonarson; Ruben C Gur; Raquel E Gur |
Related Documents
:
|
10418153 - Peripheral encoding of behaviorally relevant acoustic signals in a vocal fish: single t... 705353 - Changing response measures alters temporal summation in the receptor and spike potentia... 11833613 - Psychophysical estimates of cochlear phase response: masking by harmonic complexes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-2 |
Journal Detail:
|
Title: NeuroImage Volume: - ISSN: 1095-9572 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Positron emission tomography assessment of 8-OH-DPAT-mediated changes in an index of cerebral glucos...
Next Document: Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: A ...