Document Detail

Impact of imipenem treatment on colonic mycobiota in rats with double-hit sepsis.
MedLine Citation:
PMID:  23673098     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Broad-spectrum antibiotic administration promotes intestinal colonization of exogenous fungal pathogens in healthy animals and has been recognized as one of the risk factors of invasive fungal infection in clinical settings. It is unclear whether broad-spectrum antibiotic treatment would change the intestinal mycobiota without exogenous fungal challenge in the context of sepsis.
METHODS: We established a rat model of double-hit sepsis using burn injury and endotoxin challenge. Rats with burn injury or double-hit sepsis received imipenem treatment for 3 days or 9 days, and their colon contents were sampled for selective fungal culture and isolation counts.
RESULTS: Imipenem treatment promoted the overgrowth of the commensal fungus Geotrichum capitatum in rats with burn injury. Imipenem treatment also promoted colon colonization by exogenous fungi in rats with burn injury and double-hit sepsis, including Trichosporon cutaneum, Candida albicans, Candida krusei, and Candida glabrata. A longer duration of imipenem treatment had a stronger impact on colon colonization by exogenous fungi.
CONCLUSION: Imipenem treatment facilitates the overgrowth of commensal fungi and colonization by exogenous, potentially pathogenic fungi in the colons of rats with burn injury or double-hit sepsis.
Jun Guan; Shao-Ze Liu; Zhao-Fen Lin; Wen-Fang Li; Xue-Feng Liu; De-Chang Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  126     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1850-4     Citation Subset:  IM    
Department of Critical Care and Emergency Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
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